Results 221 to 230 of about 3,278,641 (315)

Automated modeling to high level-of-detail composite object using spatial BIM objects and properties. [PDF]

Sci Rep
Lee JK, Cho D, Kim Y, Mo Y.
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Impact of anatomical adaptation in cemented femoral stems on mechanical properties and alignment. [PDF]

Sci Rep
Shimizu T, Oue T, Ishijima T, Fujiwara M, Hasebe Y, Uetsuki K, Iwasaki N, Takahashi D.   +7 more
europepmc   +1 more source

Review of: "Many types of nanosensors are designed using CP nanomaterials for nanobiological applications. (Conductive surface) The oxidation of conductive polymeric materials" [PDF]

Christina G.S. Palmer
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Patellar Clunk Syndrome: A Systematic Review of Risk Factors and Treatment. [PDF]

Arthroplast Today
Hedeman M, Lemos J, Guerra C, Winslow H, Sharma A, Werry WD, Aurigemma P, Samuelsen B, Lemos MJ.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Optimizing Stability in Dynamic Small-Molecule Binding Proteins. [PDF]

J Am Chem Soc
Scherer M, Kriegel M, Höcker B, Fleishman SJ.   +3 more
europepmc   +1 more source

Optimal design for the Elisa type of immunoassays : classical calibration versus parallel fitting : theory and methods

, 2009
Principal Ndlovu
openalex   +1 more source