Results 301 to 310 of about 31,306,322 (385)

Compositional Effects on the Performance of High-Permeability Emulsified Asphalt for Prime Coat Applications. [PDF]

Materials (Basel)
Qin Z, Liu X, Zheng S, Pan S, Li X, Jia J, Xiong H.   +6 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Engagement With Conversational Agent-Enabled Interventions in Cardiometabolic Disease Self-Management: Systematic Review.

JMIR Mhealth Uhealth
Kashyap N, Sebastian AT, Lynch C, Jansons P, Maddison R, Dingler T, Oldenburg B.   +6 more
europepmc   +1 more source

Coupled modeling framework for proactive design of debris-flow barrier placements. [PDF]

Sci Rep
Lee DH, Lee SR, Park JY.
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

A 90-100 GHz SiGe BiCMOS 6-Bit Digital Phase Shifter with a Coupler-Based 180° Unit for Phased Arrays. [PDF]

Micromachines (Basel)
Shen H, Zhang H, Pu Y, Wang C, Li B, Tang X, Zeng X, Luo J.   +7 more
europepmc   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. [PDF]

Proc Natl Acad Sci U S A
Sevgen E, Moller J, Lange A, Parker J, Quigley S, Mayer J, Srivastava P, Gayatri S, Hosfield D, Dilks C, Buchanan C, Speltz T, Korshunova M, Livne M, Gill M, Ranganathan R, Costa AB, Ferguson AL.   +17 more
europepmc   +1 more source

Comparative Analysis of Structural Efficiency of Steel Bar Hyperbolic Paraboloid Modules. [PDF]

Materials (Basel)
Dzwierzynska J, Lechwar P.
europepmc   +1 more source

Addressing binge eating in people with type 2 diabetes: Co-creating and feasibility testing dialogue tools based on a design thinking approach. [PDF]

Int J Nurs Stud Adv
Lindgreen P, Clausen L, Grønbæk HN, Andersen CH, Ismail K, Cleal B.   +5 more
europepmc   +1 more source