Results 41 to 50 of about 23,695 (260)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

MAXIMUM LIKELIHOOD ESTIMATION OF THE KUMARASWAMY MARSHAL-OLKIN LINDELY -LOMAX DISTRIBUTION FROM TYPE II CENSORED SAMPLES [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-Tiğāriyyaẗ
This paper introduces and studies the Kumaraswamy Marshall–Olkin Lindley–Lomax (KMOLL) distribution, a new and flexible four-parameter lifetime model capable of capturing a variety of hazard rate shapes, including increasing, decreasing, bathtub, and ...
أحمد أبو المعاطي, عبدالحميد عيسى   +1 more
doaj   +1 more source

Maximum Likelihood Estimation for Non-Linear Failure Rate & Progressive Censored Samples [PDF]

The Egyptian Statistical Journal, 1991
The problem of maximum likelihood estimation of the three unknown parameters of a non-linear failure rate is discussed using progressive censored type II samples.
S.A. Salem
doaj   +1 more source

Test for the Exponential Distribution Based on Multiply Type-II Censored Samples [PDF]

Communications for Statistical Applications and Methods, 2006
In this paper, we develope three modified empirical distribution function type tests, the modified Cramer-von Mises test, the modified Anderson-Darling test, and the modified Kolmogorov-Smirnov test for the two-parameter exponential distribution with unknown parameters based on multiply Type-II censored samples.
Suk-Bok Kang, Sang-Ki Lee
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Estimating the Shape Parameter of Topp–Leone Distribution Based on Progressive Type II Censored Samples

Revstat Statistical Journal, 2016
In this paper, classical and Bayesian point estimations of the Topp–Leone distribution shape parameter are studied when the sample is progressive Type II censored. The maximum likelihood estimator (MLE) of the unknown parameter is proposed.
Husam Awni Bayoud
doaj   +1 more source

Classical and Bayesian Inference on Finite Mixture of Exponentiated Kumaraswamy Gompertz and Exponentiated Kumaraswamy Fréchet Distributions under Progressive Type II Censoring with Applications

Mathematics, 2022
A finite mixture of exponentiated Kumaraswamy Gompertz and exponentiated Kumaraswamy Fréchet is developed and discussed as a novel probability model. We study some useful structural properties of the proposed model. To estimate the model parameters under
Refah Alotaibi, Ehab M. Almetwally, Indranil Ghosh, Hoda Rezk   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Structural Inference on Progressively Censored Weibull Data of Type II [PDF]

The Egyptian Statistical Journal, 1978
Using the structural approach to inference, this paper studies the inference on the two-parameter Weibull distribution based on type II censored samples.
Aly Sherif
doaj   +1 more source