Results 1 to 10 of about 14,118,465 (281)

Inclusion of non-inferiority analysis in superiority-based clinical trials with single-arm, two-stage Simon's design

Contemporary Clinical Trials Communications, 2020
Introduction: Non-inferiority (NI) analysis is not usually considered in the early phases of clinical development. In some negative phase II trials, a post-hoc NI analysis justified additional phase III trials that were successful.
Miguel Sampayo-Cordero, Bernat Miguel-Huguet, José Pérez-García, David Páez, Ángel L. Guerrero-Zotano, Javier Garde-Noguera, Elena Aguirre, Esther Holgado, Elena López-Miranda, Xin Huang, Andrea Malfettone, Antonio Llombart-Cussac, Javier Cortés   +12 more
doaj   +1 more source

Identifying early-measured variables associated with APACHE IVa providing incorrect in-hospital mortality predictions for critical care patients

Scientific Reports, 2021
APACHE IVa provides typically useful and accurate predictions on in-hospital mortality and length of stay for patients in critical care. However, there are factors which may preclude APACHE IVa from reaching its ceiling of predictive accuracy.
Shuo Feng, Joel A. Dubin
doaj   +1 more source

A significant minimization of Pearson’s X2 statistics in 2x2 contingency tables: preliminary results for small samples

Epidemiology, Biostatistics and Public Health, 2018
The Pearson’s chi-square test or X2 test represents a nonparametric test more used in Medicine, Biology and Social Sciences, but it introduces some error for 2x2 contingency tables, therefore Yates introduces a continuity correction.
Nicola Serra
doaj   +1 more source

A Response-Adaptive Method for Design of Validation Experiments in Computational Mechanics

Applied Sciences, 2020
For model verification and validation (V & V) in computational mechanics, a hypothesis test for the validity check (HTVC) is useful, in particular, with a limited number of experimental data.
Byung C. Jung, Yun-Ho Shin, Sang Hyuk Lee, Young Cheol Huh, Hyunseok Oh   +4 more
doaj   +1 more source

Curbing type I and type II errors [PDF]

European Journal of Epidemiology, 2010
The statistical education of scientists emphasizes a flawed approach to data analysis that should have been discarded long ago. This defective method is statistical significance testing. It degrades quantitative findings into a qualitative decision about the data.
openaire   +2 more sources

Classical Versus Bayesian Error-Controlled Sampling Under Lognormal Distributions with Type II Censoring

Entropy
This paper presents a comparative study of classical and Bayesian risks in the design of optimal failure-censored sampling plans for lognormal lifetime models.
Huasen Zhou, Wenhao Gui
doaj   +1 more source

Sample size estimation in clinical trial

Perspectives in Clinical Research, 2010
Every clinical trial should be planned. This plan should include the objective of trial, primary and secondary end-point, method of collecting data, sample to be included, sample size with scientific justification, method of handling data, statistical ...
Tushar Vijay Sakpal
doaj  

Putative panmixia in restricted populations of Trypanosoma cruzi isolated from wild Triatoma infestans in Bolivia. [PDF]

PLoS ONE, 2013
Trypanosoma cruzi, the causative agent of Chagas disease, is subdivided into six discrete typing units (DTUs; TcI-TcVI) of which TcI is ubiquitous and genetically highly variable.
Christian Barnabe, Rosio Buitrago, Philippe Bremond, Claudia Aliaga, Renata Salas, Pablo Vidaurre, Claudia Herrera, Frédérique Cerqueira, Marie-France Bosseno, Etienne Waleckx, Simone Frédérique Breniere   +10 more
doaj   +1 more source

Alternativas para o teste t com variâncias heterogêneas avaliadas por meio de simulação Alternatives for evaluating t test with heterogeneous variances by monte carlo simulation

Ciência e Agrotecnologia, 2003
Conduziu-se este trabalho com o objetivo de avaliar os riscos de se tomar decisões erradas (erro tipo I e erro tipo II), com o aumento da diferença entre as variâncias populacionais, por meio de simulação computacional, utilizando-se o teste t de Student
Roberta Bessa Veloso Silva, Daniel Furtado Ferreira   +1 more
doaj   +1 more source

Effects of biomarker diagnostic accuracy on biomarker-guided phase 2 trials

Contemporary Clinical Trials Communications, 2019
Recent advancements in genomics have attracted attention towards biomarker-guided trials. These trials aim to identify therapies that target diseases based on their genetic profile, and are especially common in cancer research.
Jay JH. Park, Ofir Harari, Louis Dron, Edward J. Mills, Kristian Thorlund   +4 more
doaj   +1 more source