Results 81 to 90 of about 14,713,155 (294)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Epidemiology, Biostatistics and Public Health, 2022 The Pearson’s chi-square test or X2 test represents a nonparametric test more used in Medicine, Biology and Social Sciences, but it introduces some error for 2x2 contingency tables, therefore Yates introduces a continuity correction.
Nicola Serra
doaj
Type II error rates of the co-occurrence null model test.
, 2016 Each panel represents a different criterion for determining the significance of the null model: inclusive p-values (≤ or ≥), exclusive p-values (), and SES.
Brandon S. Schamp (497231) +2 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Effects of biomarker diagnostic accuracy on biomarker-guided phase 2 trials
Contemporary Clinical Trials Communications, 2019 Recent advancements in genomics have attracted attention towards biomarker-guided trials. These trials aim to identify therapies that target diseases based on their genetic profile, and are especially common in cancer research.
Jay JH. Park +4 more
doaj +1 more source
An Inequality of Ostrowski-Grüss Type for Twice Differentiable Mappings and Applications in Numerical Integration [PDF]
, 1998 In this paper we derive a new integral inequality of Ostrowski-Grüss type and apply it to estimate the error bounds for some numerical quadrature ...
Roumeliotis, John +2 more
core +3 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Ciência e Agrotecnologia, 2003 Conduziu-se este trabalho com o objetivo de avaliar os riscos de se tomar decisões erradas (erro tipo I e erro tipo II), com o aumento da diferença entre as variâncias populacionais, por meio de simulação computacional, utilizando-se o teste t de Student
Roberta Bessa Veloso Silva +1 more
doaj +1 more source