Results 71 to 80 of about 5,477,919 (290)

Review of Linac-Ring Type Collider Proposals

, 2010
There are three possibly types of particle colliders schemes: familiar (well known) ring-ring colliders, less familiar however sufficiently advanced linear colliders and less familiar and less advanced linac-ring type colliders.
A. N. AKAY, Ben-Zvi I., Ciftci A. K., Gladilin L., H. KARADENIZ, S. SULTANSOY, Sultansoy S., Sultansoy S., Sultansoy S., Telnov V. I., Wagner A.   +10 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Production of OER: a quest for efficiency [PDF]

, 2010
In most initiatives to publish Open Educational Resources (OER), the production of OER is the activity with the highest costs. Based on literature and personal experiences a list of relevant characteristics of production processes for OER are determined.
Lane, Andrew, Schuwer, Robert, Valkenberg, Wllem van, Wilson, Tina   +3 more
core  

Finite Domain Anomalous Spreading Consistent with First and Second Law

, 2009
After reviewing the problematic behavior of some previously suggested finite interval spatial operators of the symmetric Riesz type, we create a wish list leading toward a new spatial operator suitable to use in the space-time fractional differential ...
Abate, Barkai, Benson, Benson, Berkowitz, Calvo, Caputo, Chechkin, Chechkin, Chechkin, Cushman, del-Castillo-Negrete, Gorenflo, Kilbas, Krepysheva, Krepysheva, Mainardi, Mainardi, Metzler, Metzler, Metzler, Montroll, Montroll, Néel, P.P. Valkó, Paradisi, Piryatinska, Podlubny, Podlubny, Saichev, Scalas, Schneider, Shlesinger, Valkó, van Milligen, X.H. Zhang, Zaslavsky, Zhang, Zhang, Zhang, Zoia   +40 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

LOS LIBROS DE LA NACIÓN: LIBROS RAROS Y PATRIMONIO EN MARTÍN SARMIENTO

Cuadernos de Ilustración y Romanticismo, 2017
We analyze a list of rare Spanish books by Martin Sarmiento, taking into account the theorizing about this type of works that was published during the seventeenth and eighteenth centuries, as well as the author’s conception of heritage that began to be ...
Concha Varela-Orol
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Patrimoine rebelle à Guanajuato

Cahiers des Amériques Latines, 2007
The town of Guanajuato, capital of the Mexican state of the same name, has been part of the list of UNESCO’s world heritage since 1988. This label constitutes an invaluable tool for economic development.
Pierre-Mathieu Le Bel, Luzma Fabiola Nava   +1 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source