Results 211 to 220 of about 4,940,107 (249)

Self-supervised reservoir computing with spatial-temporal encoding for identifying critical transitions. [PDF]

Nat Commun
Yang N, Kurths J, Liu R, Chen P.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Charting spatial ligand-target activity using Renoir. [PDF]

Nat Commun
Rao N, Kumar T, Kazemi D, Hou S, Khakpoor A, Eapen MM, Pai R, Qiao L, Mishra A, Ginhoux F, Chan JKY, George J, Sharma A, Zafar H.   +13 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Skin Microbiota Diversity Is Associated with Biophysical Properties Across Healthy Human Skin Types. [PDF]

Microorganisms
Kadoya R, Kondo A, Matsukawa A, Kuribayashi A, Uemura E, Tanaka H.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pervasive and programmed nucleosome distortion on single chromatin fibres. [PDF]

Nature
Yang MG, Richter HJ, Wang S, McNally CP, Moore CM, Emadi A, Harris NE, Dhillon S, Maresca M, Pan H, Saunders H, Yang R, Ostrowski MS, Anderson EC, de Wit E, Maher JJ, Fan Y, Narlikar GJ, Nora EP, Willenbring H, Goodarzi H, Ramani V.   +21 more
europepmc   +1 more source

Paediatric and Adult Solid Tumours Exhibiting NTRK Gene Fusions in Australia, 2020-2044: A Population-Based Statistical Modelling Study. [PDF]

Cancer Med
Luo Q, Kang YJ, Cuff J, Zalcberg J, Canfell K, Steinberg J.   +5 more
europepmc   +1 more source

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types. [PDF]

PLoS Genet
Sauty SM, Shine J, Bostan H, Li JL, Mieczkowski PA, Loeser RF, Diekman BO, Gordenin DA.   +7 more
europepmc   +1 more source