Results 161 to 170 of about 75,471 (306)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan   +11 more
wiley   +1 more source

Spatial spillovers in public expenditure on a municipal level in Spain

open access: yes, 2017
F. López   +2 more
semanticscholar   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng   +7 more
wiley   +1 more source

LAND USE, POPULATION DISTRIBUTION, AND PUBLIC SERVICE EXPENDITURES OF LOCAL GOVERNMENTS

open access: yes
Local governments provide more or less similar and comparable public services like police protection, fire control, roads, water and sewer, parks and recreation, public improvements, planning and zoning, and general administrative services to the ...
Begashaw, Getachew W.
core  

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

open access: yesAdvanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu   +9 more
wiley   +1 more source

The importance of public investment for reducing rural poverty in middle-income countries [PDF]

open access: yes
This study estimates the impacts of different types of government expenditure on agricultural growth and rural poverty in Thailand. The results show that, despite Thailand's middle-income status, public investments in agricultural R&D, irrigation, rural ...
Methakunnavut, Nuntaporn   +2 more
core  

Quantifying public and private investment in biopharmaceutical R&D: a study of seven middle- and high-income countries. [PDF]

open access: yesJ Pharm Policy Pract
Fowler A   +6 more
europepmc   +1 more source

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