Results 161 to 170 of about 1,580,393 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A mitochondrial-stress adipocyte-macrophage circuit sustaining metaflammation in human type 2 diabetic adipose tissue. [PDF]

Front Immunol
Ji H, Cao T, Tan Z, Zheng R, Bian J, Lin W, Xu X, Yuan C, Shao Y, Chen H, Du J.   +10 more
europepmc   +1 more source

Communicating evidence-based information on cancer prevention to state-level policy makers.

Journal of the National Cancer Institute, 2011
R. Brownson, E. Dodson, K. Stamatakis, C. Casey, M. Elliott, D. Luke, Christopher G Wintrode, M. Kreuter   +7 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Local transcriptional covariation produces accurate estimates of cell phenotype. [PDF]

Bioinformatics
Ozbay S, Parekh A, Singh R.
europepmc   +1 more source

Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells

Proceedings of the National Academy of Sciences of the United States of America, 2017
R. Bargaje, Kalliopi Trachana, Martin N. Shelton, Christopher S. McGinnis, J. Zhou, Cora H. Chadick, Savannah M. Cook, Christopher Cavanaugh, Sui Huang, L. Hood   +9 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Microbiota-specific serum IgG links gut and joints through immune-endothelial crosstalk in arthritis. [PDF]

Front Microbiol
Schmid E, Otterbein N, Ariyeloye S, Danzer H, Frech M, Naschberger E, Becerra MM, Sarter K, Schett G, Kastbom A, Svärd A, Wielockx B, Zaiss MM.   +12 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

DAFRL: a dynamic adaptive mean field game-based multi-agent cooperative decision-making method. [PDF]

Sci Rep
Tang Y, Fan C, Yu D.
europepmc   +1 more source