Results 171 to 180 of about 709,899 (268)

Raw and normalized count data for "Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling"

, 2019
Kieran R. Campbell
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Innovative Chorioallantoic Membrane Model as Valuable Tool in Diagnostics and Testing of Domestic Animal Cancers. [PDF]

Transbound Emerg Dis
Sczasny A, Gubernator J, Jaromin A, Chen N.   +3 more
europepmc   +1 more source

Targeting multiple types of tumors using NKG2D-coated iron oxide nanoparticles. [PDF]

Nanotechnology, 2014
Wu MR, Cook WJ, Zhang T, Sentman CL.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Macroscopic growth patterns and their molecular implications in gastric carcinoma: toward risk stratification via borrmann classification. [PDF]

BMC Gastroenterol
Issin G, Demir F, Cagatay DV, Bakkaloglu IG, Gamsizkan M, Yildiz Z, Yilmaz I, Ozmen S, Zemheri IE, Demiriz M, Sayar I, Gunal A.   +11 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Benign Epithelial Salivary Neoplasms: Single-Centered Histopathologic and Clinicodemographic Romanian Retrospective Study. [PDF]

Clin Pract
Costin CA, Grigoraș A, Andriescu EC, Amalinei C.   +3 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Performance of Routine MRI Reporting for Parapharyngeal Space Tumors: A Retrospective Radiologic-Pathologic Comparison. [PDF]

J Clin Med
Alshahrani M, Almayouf M, Doubi A, Alotaibi O, Almatrafi S, AlQahtani K, Aldhahri S, Albarrak M, Alessa M, Albosaily A, Alzahrani F.   +10 more
europepmc   +1 more source