Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase [PDF]
, 2013 Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle.
Bastie, Claire C. +8 more
core +1 more source
Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders [PDF]
, 2009 The myeloproliferative disorders (MPDs) are a group of haematopoietic stem cell diseases, characterised by proliferation of one or more cells of the myeloid lineage.
Hidalgo-Curtis, Claire
core +1 more source
Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach [PDF]
, 2005 Background: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s)
RJ Edwards +8 more
core +1 more source
Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]
, 2005 This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core
Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]
, 2009 Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana +11 more
core +1 more source
Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes [PDF]
, 2007 The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β2 integrin-mediated leukocyte activation.
Jakus, Zoltán +18 more
core +2 more sources
JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]
, 2006 MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core +1 more source
Haematologica, 2018 Ibrutinib and acalabrutinib are irreversible inhibitors of Bruton tyrosine kinase used in the treatment of B-cell malignancies. They bind irreversibly to cysteine 481 of Bruton tyrosine kinase, blocking autophosphorylation on tyrosine 223 and ...
Phillip L.R. Nicolson +14 more
doaj +1 more source
Protein recruitment to receptor tyrosine kinase-mediated early signalling complexes. [PDF]
, 2007 Receptor tyrosine kinase (RTK) signalling regulates the activation of numerous cellular processes in response to various external stimuli. Spatio-temporal regulation of protein recruitment to activated tyrosine kinase receptors is important for the ...
Schller, A.C.
core
Middle East Journal of Cancer, 2013 Background: According to numerous studies, FMS-like tyrosine kinase 3, internal tandem duplication, and the D835 mutation are associated with a poor prognostic clinical outcome in acute myeloid leukemia patients. Detection of the FMS-like tyrosine kinase
Hind Dehbi +4 more
doaj