Results 321 to 330 of about 857,410 (384)

Outcomes of pregnancy in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitors. [PDF]

Cancer
Kondo T, Matsuki E, Takaku T, Watanabe N, Yoshida C, Okada M, Murai K, Kodama T, Takahashi N, Kimura S, Matsumura I, Preg‐CML/Japan Study Investigators.   +11 more
europepmc   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +1 more source

A review of Bruton's tyrosine kinase inhibitors in multiple sclerosis. [PDF]

Ther Adv Neurol Disord
Airas L, Bermel RA, Chitnis T, Hartung HP, Nakahara J, Stuve O, Williams MJ, Kieseier BC, Wiendl H.   +8 more
europepmc   +1 more source

Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins

Angewandte Chemie, EarlyView.
The sequence (PQYQP), derived from the SRC protein, was combined with the self‐assembly motif (Nap‐FF) to produce intrinsically disordered peptide (IDP) assemblies that form cell‐compatible hydrogels via enzyme‐instructed self‐assembly (EISA). Abstract Intrinsically disordered regions (IDRs) are ubiquitous in proteins, orchestrating complex cellular ...
Yuchen Qiao, Ayisha Zia, Adrianna Shy, Grace Wu, Matthew Chu, Zhiyu Liu, Fengbin Wang, Bing Xu   +7 more
wiley   +1 more source

Comparative safety profile of tyrosine kinase inhibitors in NSCLC: a network meta-analysis of hypertension and thrombotic risks. [PDF]

Front Pharmacol
Tan M, Pu C, Wang Z, Jin C.
europepmc   +1 more source

Watching the Barn Door Open—Timing CML Stem Cell Allografts

American Journal of Hematology, EarlyView.
Jeffrey H. Lipton
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +1 more source

Cardiovascular toxicity risk assessment of tyrosine kinase inhibitors: a pharmacovigilance study using the VigiBase database. [PDF]

Front Pharmacol
Igawa Y, Hamano H, Esumi S, Takeda T, Kajizono M, Kikuoka R, Kimura I, Zamami Y.   +7 more
europepmc   +1 more source

Outcome of Chronic Myeloid Leukemia Patients Not in Deep Molecular Response: Results From the GIMEMA LabNet CML Network Database

American Journal of Hematology, EarlyView.
Fabio Stagno, Rosalba Cucci, Giovanni Marsili, Fausto Castagnetti, Sara Galimberti, Barbara Izzo, Federica Sorà, Simona Soverini, Monica Messina, Alfonso Piciocchi, Massimiliano Bonifacio, Daniela Cilloni, Alessandra Iurlo, Giovanni Martinelli, Gianantonio Rosti, Paola Fazi, Marco Vignetti, Massimo Breccia, Alessandro Allegra, Fabrizio Pane   +19 more
wiley   +1 more source