Results 91 to 100 of about 1,485,018 (348)

Peripherin Is Tyrosine‐Phosphorylated at Its Carboxyl‐Terminal Tyrosine [PDF]

Journal of Neurochemistry, 1998
Abstract: Peripherin is a type III intermediate filament present in peripheral and certain CNS neurons. We report here that peripherin contains a phosphotyrosine residue and, as such, is the only identified intermediate filament protein known to be modified in this manner.
J M, Angelastro, C L, Ho, T, Frappier, R K, Liem, L A, Greene   +4 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes

International Journal of Analytical Chemistry, 2016
Phosphorylation of tyrosine residues in proteins, as well as their dephosphorylation, is closely related to various diseases. However, this phosphorylation is usually accompanied by more abundant phosphorylation of serine and threonine residues in the ...
Jun Sumaoka, Hiroki Akiba, Makoto Komiyama   +2 more
doaj   +1 more source

Homodimerization and intermolecular tyrosine phosphorylation of the Tyk‐2 tyrosine kinase [PDF]

FEBS Letters, 1995
The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFNα. In this report we show a ligand‐independent interaction between Tyk‐2 and Jak‐1 kinases. We also demonstrate that the Tyk‐2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation.
Domanski, Paul, Yan, Hai, Witte, Michael M., Krolewski, John, Colamonici, Oscar R.   +4 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury

Frontiers in Molecular Neuroscience
Effective synaptic inhibition relies on KCC2, a K+-Cl− cotransporter that forms oligomers to extrude chloride. However, how phosphorylation regulates oligomerization remains unclear.
Sylvie Liabeuf, Cecile Brocard, Jacques-Olivier Coq, Laurent Vinay, Frederic Brocard   +4 more
doaj   +1 more source

Novel Regulation of Parkin Function Through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

Journal of Neuroscience, 2011
Mutations in parkin, an E3 ubiquitin ligase, are the most common cause of autosomal-recessive Parkinson's disease (PD). Here, we show that the stress-signaling non-receptor tyrosine kinase c-Abl links parkin to sporadic forms of PD via tyrosine ...
S. Imam, Qing Zhou, A. Yamamoto, A. J. Valente, Syed F. Ali, M. Bains, J. Roberts, P. Kahle, R. A. Clark, Sen-Lin Li   +9 more
semanticscholar   +1 more source

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]

, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core  

Effect of PAO on tyrosine phosphorylation.

, 2016
Effect of PAO on tyrosine phosphorylation.
Martin Sztacho (3229086), Maria Arantzazu Sanchez-Fernandez (164567), Sandra Segeletz (3229089), Cornelia Czupalla (613749), Christian Niehage (219581), Bernard Hoflack (164600)   +5 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source