Results 41 to 50 of about 306 (158)
Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain +5 more
wiley +1 more source
Techno‐Functional Properties and Pharmaceutical Potential of Jackfruit Peel, Pulp, and Seeds
Food Science &Nutrition, Volume 13, Issue 11, November 2025.FTIR showed that the pulp had the highest number of peaks. 8 volatile compounds were present in different percentages in the three samples. ABSTRACT Jackfruit contains a significant quantity of secondary metabolites that are classified as high‐value biological compounds.
Stéphano Tambo Téné +3 more
wiley +1 more source
Supplemental technologies of liver ultrasound investigation at the 1-st type tyrosinemia in pediatrics [PDF]
, 2015 Aim of investigation. To carry out objective estimation of liver parenchyma state in children with the 1-st type hereditary tyrosinemia (НТ-1) by ultrasound method with quantitative estimation of hepatic parenchyma pattern.Material and methods.
G. M. Dvoryakovskaya +3 more
core +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source
Biomarker discovery and food allergy profiling distinguishes DOCK8 deficiency from atopic dermatitis [PDF]
, 2019 Metabolomics is metabolites profiling in biological matrices and is a key tool for biomarker discovery. Over the last decade, metabolomics studies have identified several relevant biomarkers involved in complex clinical phenotypes using diverse ...
Jacob, Minnie
core +1 more source
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.ABSTRACT Liver transplantation (LTx) has become, over the years, an increasingly used therapeutic option in patients with inherited metabolic diseases (IMD). Initially performed for Tyrosinemia Type I and ornithine transcarbamylase deficiency, it now accounts as the second indication for pediatric transplants worldwide. The use of LTx has been extended
Andrea Pietrobattista +3 more
wiley +1 more source
Newborn screening for Tyrosinemia type 1 using succinylacetone – a systematic review of test accuracy [PDF]
, 2017 Background: Tyrosinemia type 1 is an autosomal recessive disorder of amino acid metabolism. Without treatment, death in childhood is common. Treatment with nitisinone and dietary restrictions are associated with improved outcomes; some studies suggest ...
Clarke, Aileen +7 more
core +2 more sources
Trial Readiness: Understanding the Natural History of Rare Diseases
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.ABSTRACT Inherited metabolic diseases (IMD) represent the largest and still growing group of treatable genetic disorders and are increasingly amenable to targeted interventions that achieve varying degrees of prognostic improvement. Innovative therapies are on the horizon and offer promising opportunities for disease‐changing treatment for a variety of
Thomas Opladen +6 more
wiley +1 more source
Serum alpha-fetoprotein levels in neonatal cholestasis [PDF]
, 2013 Alpha-fetoprotein (AFP) is used as a tumor marker for hepatocellular carcinoma, hepatoblastoma and germ cell tumors. It may also be elevated in infants with some hepatobiliary disorders. The mechanism of AFP elevation in neonatal cholestasis is not known.
Aysel Yüce +7 more
core +1 more source