Results 121 to 130 of about 5,768,673 (280)

A deep learning aided bone marrow segmentation of quantitative fat MRI for myelofibrosis patients

Frontiers in Oncology
PurposeTo automate bone marrow segmentation within pelvic bones in quantitative fat MRI of myelofibrosis (MF) patients using deep-learning (DL) U-Net models.MethodsAutomated segmentation of bone marrow (BM) was evaluated for four U-Net models: 2D U-Net ...
Humera Tariq, Lubomir Hadjiiski, Dariya Malyarenko, Moshe Talpaz, Kristen Pettit, Gary D. Luker, Brian D. Ross, Thomas L. Chenevert   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A 3D residual U-Net with attention-driven spatial pyramid pooling for accurate multimodal MRI brain tumor segmentation

Discover Artificial Intelligence
Medical imaging plays a crucial role in the accurate detection and localization of brain tumors, which is essential for effective clinical diagnosis and treatment planning.
Retinderdeep Singh, Chander Prabha, Navita Gupta, Durgesh Nandan, Chandan Kumar Choubey   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Generalized U-Net for automatic liver segmentation and R2* estimation for assessment of iron overload using MRI

BMC Medical Imaging
Background Although R2*-MRI is extensively validated for assessing liver iron concentration (LIC), techniques for robust and automatic liver extraction remain underdeveloped, limiting clinical workflow and adoption for automated LIC reporting. Hence this
Utsav Shrestha, Zachary R. Abramson, Stephan Kannengiesser, Xiaodong Zhong, Cara E. Morin, Aaryani Tipirneni-Sajja   +5 more
doaj   +1 more source

Early macular edema recognition after cataract surgery based on U-Net assisted optical coherence tomography

Journal of Radiation Research and Applied Sciences
Objective: The optical coherence tomography (OCT) model of macular edema in postoperative cataract patients is constructed by using convolutional neural network (CNN) U-Net, and its value is evaluated by relevant indicators. Methods: From January 2020 to
Min Liu, Shuoming Wang
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source