Results 221 to 230 of about 4,877,471 (257)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source
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U–Pb geochronology of speleothems by MC-ICPMS

Quaternary Geochronology, 2006
Abstract Building upon the work of Richards et al. [1998. U–Pb dating of a speleothem of Quaternary age. Geochimica et Cosmochimica Acta 62, 3683–3688], we have developed a method for precise dating of speleothems beyond the range of the U–Th technique using the U–Pb decay scheme.
WOODHEAD J   +6 more
openaire   +2 more sources

U-Pb age of the Baltoro granite, northwest Himalaya, and implications for monazite U-Pb systematics

Geology, 1989
The Baltoro granite is a major late- to post-tectonic plutonic phase of the Karakoram batholith of the northwest Himalaya in northern Pakistan. U-Pb zircon analyses indicate both emplacement at 21.0 ±0.5 Ma and significant Precambrian zircon inheritance.
Randall R. Parrish, Rein Tirrul
openaire   +1 more source

U-Pb AGE OF THE CHATTANOOGA SHALE

Geological Society of America Bulletin, 1960
An attempt was made to date the upper black unit of the Gassaway member of the Chattanooga shale which carries the maximum U/Pb ratio. Three samples were analyzed by isotopic dilution techniques. The U238-Pb206 ages on all 3 samples agreed within their experimental errors. The average of the two samples with reasonably small errors gave an apparent age
J. C. COBB, J. L. KULP
openaire   +1 more source

Staurolite as an isotopic U–Pb geochronometer

Geology of Ore Deposits, 2016
A new approach is suggested for measuring the real U–Pb and Pb–Pb ages of rock-forming metamorphic staurolite. Previously, two approaches have been used for this purpose: (1) measurement of the lead isotopic compositions, uranium and lead contents in leach substance as a product of the step-leaching technique; age is calculated by plotting the Pb–Pb ...
L. K. Levskii, A. F. Lobikov
openaire   +1 more source

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