Results 251 to 260 of about 163,795 (290)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

U-Pb TIMS zircon age constraints on the Tardree Rhyolite zircon fission track standard [PDF]

, 2008
Chew, D., Corfu, F., Ganerød, M., Meade, F., Troll, V.   +4 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

U-Pb LA-ICP-MS age determinations of growth impulses in zircons from Carboniferous post-orogenic granites, Sierra de Velasco (NW-Argentina) [PDF]

, 2009
Gerdes, Axel, Grosse, Pablo, Rossi, Juana Norma, Söllner, Frank, Toselli, Alejandro J.   +4 more
core  

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U–Pb geochronology of speleothems by MC-ICPMS

Quaternary Geochronology, 2006
Abstract Building upon the work of Richards et al. [1998. U–Pb dating of a speleothem of Quaternary age. Geochimica et Cosmochimica Acta 62, 3683–3688], we have developed a method for precise dating of speleothems beyond the range of the U–Th technique using the U–Pb decay scheme.
WOODHEAD J, HELLSTROM J, MAAS R, DRYSDALE R, ZANCHETTA, GIOVANNI, DEVINE P, TAYLOR E.   +6 more
openaire   +2 more sources

A new method integrating high-precision U–Pb geochronology with zircon trace element analysis (U–Pb TIMS-TEA)

Geochimica et Cosmochimica Acta, 2010
Increased precision in isotope-dilution thermal ionization mass spectrometry (ID-TIMS) U–Pb geochronology has revealed age complexities in zircon populations that require new tools for understanding how the growth of zircon is related to geologic processes.
Schoene, B., Latkoczy, C., Schaltegger, Urs, Günther, D.   +3 more
openaire   +2 more sources

U-Pb age of the Baltoro granite, northwest Himalaya, and implications for monazite U-Pb systematics

Geology, 1989
The Baltoro granite is a major late- to post-tectonic plutonic phase of the Karakoram batholith of the northwest Himalaya in northern Pakistan. U-Pb zircon analyses indicate both emplacement at 21.0 ±0.5 Ma and significant Precambrian zircon inheritance.
Randall R. Parrish, Rein Tirrul
openaire   +1 more source