Results 161 to 170 of about 151,775 (355)
Discovery of an albite gneiss from the Ile de Groix (Armorican Massif, France): geochemistry and LA-ICP-MS U-Pb geochronology of its Ordovician protolith [PDF]
, 2018 For the first time, an albite orthogneiss has been recognised and dated within the HP-LT blueschist facies metabasites and metapelites of the Ile de Groix.
Ballèvre, Michel +4 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Timing of thermal events in eastern Dronning Maud Land, East Antarctica [PDF]
, 2003 Using cathodoluminescence (CL)images,the zircons analyzed by K. Shiraishi et al.(J.Geol.,102,47,1994) for SHRIMP U-Pb dating (prior to the use of CL images) have been re-examined in order to unravel the periods of multiple zircon growth in eastern ...
C.M. Fanning +4 more
core +1 more source
New U-Pb dates from southwestern Coast Belt, British Columbia
, 1993 Four new U-Pb dates of granitic rocks from the southwestern Coast Belt are reported. The Bodega Point pluton on Quadra Island, Bute Inlet map-area (92K), is the westernmost Coast Belt pluton at this latitude and intrudes Wrangellian stratigraphy; it has been dated at 163.8 +/- 0.4 Ma, Middle Jurassic.
J W H Monger, V J McNicoll
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
U-Pb & Hf-W dating of young zircon in mesosiderite Asuka 882023 [PDF]
, 2016 第7回極域科学シンポジウム:[OA] 南極隕石/はやぶさ12月1日（木）国立国語研究所 ...
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source