Results 71 to 80 of about 5,011,359 (270)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Thermochronology of the modern Indus River bedload: New insight into the controls on the marine stratigraphic record [PDF]

, 2004
The Indus River is the only major drainage in the western Himalaya and delivers a long geological record of continental erosion to the Arabian Sea, which may be deciphered and used to reconstruct orogenic growth if the modern bedload can be related to ...
Campbell, IH, Pringle, MS, Zhang, Xifan, Allen, Charlotte M, Ian H. Campbell, Allen, C.M., Xifan Zhang, Hodges, Kip V., Pringle, Malcolm S., Ali Athar Khan, Campbell, Ian, Pringle, Malcolm, Khan, AA, Campbell, Ian H., Andrew Carter, Hodges, KV, Clift, Peter D., Campbell, I.H., Peter D. Clift, Allen, Charlotte M., Carter, Andrew, Khan, Ali Athar, Malcolm S. Pringle, Kip V. Hodges, Zhang, X., Clift, PD, Zhang, X, Hodges, K.V., Charlotte M. Allen, Allen, CM, Hodges, Kip V, Carter, A, Clift, P.D., Khan, A.A.   +33 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Is there a Grenvillian basement in the Guerrero-Morelos Platform of Mexico?

Geologica Acta, 2007
In the Guerrero-Morelos platform (Guerrero State, Mexico) the adakitic rocks of Early Tertiary age contain abundant hornblende-rich tonalite xenoliths. Zircon crystals have been concentrated from both adakites and xenoliths, and dated using in-situ U-Pb ...
G. Levresse, J. Tritlla, E. Deloule, P. J. PINTO LINARES   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Impacts of Common Lead on Apatite U-Pb Geochronology by LA-ICP-MS: Assessment and Correction Strategies

Yankuang ceshi
Apatite is a widespread U-bearing mineral in igneous, metamorphic, and sedimentary rocks. U-Pb geochronology of apatite can provide significant information for constraining magmatic evolution processes and tracing provenance.
Tao LUO, Hanlin WANG, Songbai ZHU, Liyuan QING, Zhaochu HU   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Apatite Triple Dating (Lu–Hf, U–Pb, FT) Constrains Deformation and Cooling in the Coompana and Madura Provinces, Western Australia [PDF]

Lithosphere
Combined apatite Lu–Hf, U–Pb, and fission track (AFT) triple dating affords the opportunity to investigate the ~60 and 730°C thermal history of a study area.
Alejandra Bedoya, Stijn Glorie, Martin Hand, Christopher L. Kirkland, David E. Kelsey, Angus Nixon, Geoff Fraser   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source