Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The Effect of Removable Space Maintainer Use on Oral-Health-Related Quality of Life in Children: A Cross-Sectional Study. [PDF]
Oral Health Prev DentSaraç F +3 more
europepmc +1 more source
Noncommutative geometry of angular momentum space U(su(2)) [PDF]
, 2002 Eliezer Batista, Shahn Majid
openalex +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Sensorimotor Adaptation to a Nonuniform Formant Perturbation Is Preserved in Healthy Aging. [PDF]
J Speech Lang Hear ResCheng HS, Niziolek CA, Parrell B.
europepmc +1 more source
U-Space Environmental and Social Performance Framework
Document that describes the proposed set of indicators and measurement mechanisms to assess UAM’s social and environmental impact. It will include a summary of the conclusions of the literature review and the stakeholder consultation processes conducted to define and validate the performance framework.
openaire +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Space ionizing radiation triggers the formation of peptides and organophosphates on olivine surfaces. [PDF]
Nat CommunDing R +9 more
europepmc +1 more source
Drone performance modelling for U-space services
Objectius de Desenvolupament Sostenible::11 - Ciutats i Comunitats ...
openaire +1 more source