Results 91 to 100 of about 100,609 (297)

Renewal theory for asymmetric $U$-statistics

Electronic Journal of Probability, 2018
We extend a functional limit theorem for symmetric $U$-statistics [Miller and Sen, 1972] to asymmetric $U$-statistics, and use this to show some renewal theory results for asymmetric $U$-statistics. Some applications are given.
openaire   +5 more sources

An Edgeworth Expansion for $U$-Statistics

The Annals of Statistics, 1980
It is shown that, under some regularity conditions on the kernel, a one-sample $U$-statistic with kernel of degree two admits an asymptotic expansion with remainder term $o(N^{-1})$.
Callaert, H., Janssen, P., Veraverbeke, N.   +2 more
openaire   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Large deviations of bootstrapped U -statistics

Journal of Multivariate Analysis, 2008
This paper develops a large deviation result with Cramér series for bootstrapped U-statistics where the U-statistic has a non-degenerate, bounded kernel. The method of proof is based on the contraction technique of \textit{R. Keener, J. Robinson} and \textit{N.C. Weber} [Stat. Probab. Lett. 37, No. 1, 59--65 (1998; Zbl 0928.60016)].
Borovskikh, Yuri V., Robinson, John
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Large Eddy Simulation of the Subcritical Flow over a U-Grooved Circular Cylinder

Advances in Mechanical Engineering, 2014
With the aim of numerically replicating a drag reduction phenomenon induced by grooves presence, this paper presents a comparative large eddy simulation study of the flow over a smooth circular cylinder, and the flow over a U-grooved cylinder, at Re ...
A. Alonzo-García, C. del C. Gutiérrez-Torres, J. A. Jiménez-Bernal   +2 more
doaj   +1 more source

Experimental and Statistical Analysis of U-Shaped Polyurethane-Based Polymer Concrete under Static and Impact Loads as a Repair Material [PDF]

, 2022
Sadi Ibrahim Haruna, Han Zhu, Yasser E. Ibrahim, Jianwen Shao, Musa Adamu, AIB Farouk   +5 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source