Results 131 to 140 of about 100,609 (297)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Marginal adaptation of copings of three systems in function of two different kinds of cervical termination

Revista Ciência em Extensão, 2010
The objective of this work was to evaluate in vitro the accuracy of marginal foundation of copings of three ceramic systems: In-Ceram; IPS Empress 2 and Procera All Ceram.
Alberto Alvarenga de Oliveira, Tetsuo Saito, Simone Helena Gonçalves de Oliveira   +2 more
doaj  

A weighted U statistic for association analyses considering genetic heterogeneity. [PDF]

Stat Med, 2016
Wei C, Elston RC, Lu Q.
europepmc   +1 more source

Weak Convergence of Generalized $U$-Statistics

The Annals of Probability, 1974
Wichura (1969) studied an invariance principle for partial sums of a multi-dimensional array of independent random variables. It is shown that a similar invariance principle holds for a broad class of generalized $U$-statistics for which the different terms in the partial sums are not independent.
openaire   +3 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A weighted U-statistic for genetic association analyses of sequencing data. [PDF]

Genet Epidemiol, 2014
Wei C, Li M, He Z, Vsevolozhskaya O, Schaid DJ, Lu Q.   +5 more
europepmc   +1 more source

Conditional Dependence via U-Statistics Pruning

IEEE Signal Processing Letters
The problem of measuring conditional dependence between two random phenomena arises when a third one (a confounder) has a potential influence on the amount of information between them. A typical issue in this challenging problem is the inversion of ill-conditioned autocorrelation matrices.
Cabrera Estanyol, Ferran de, Vila Insa, Marc, Riba Sagarra, Jaume   +2 more
openaire   +2 more sources

On local U-statistic processes and the estimation of densities of functions of several sample variables [PDF]

, 2007
Evarist Giné, David M. Mason
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source