Results 241 to 250 of about 100,609 (297)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A New Approach to the Nonparametric Behrens-Fisher Problem With Compatible Confidence Intervals. [PDF]

Biom J
Schüürhuis S, Konietschke F, Brunner E.   +2 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Etiology and Clinical Correlates of Pediatric Pneumonia in Lebanon in the Era Following COVID-19 Vaccine Availability: A Multicenter Retrospective Study. [PDF]

Cureus
Fakih H, Soufan G, AlArab S, Dahrouj M.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

An integrative examination of psychological distress and its nutritional and visual correlates among young adults in Ghana. [PDF]

PLoS One
Osei Duah Junior I, Asare WO, Johnson EJ, Boateng C, Acheampong HO, Ben Kumah D, Akuffo KO.   +6 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Alkaline Phosphatase Activity in Serum as Indicator for Skeletal Maturity in Assamese Population - An Ex-Vivo Study.

J Pharm Bioallied Sci
Bhattacharjee R, Baruah N, Bora M, Khan RUA, Das SDC.   +4 more
europepmc   +1 more source

Discrepancy Between Gaze Fixation and Risk Perception in Fall Risk Scenarios Among Healthcare Professionals and Students. [PDF]

Cureus
Arihisa K, Miyaguchi H, Ohura T, Ishizuki C, Kishita R, Matsushita W.   +5 more
europepmc   +1 more source

A sequential fixed-width confidence interval for the mean of a U-statistic

, 1969
Raymond N. Sproule
openalex   +1 more source