Results 111 to 120 of about 585,442 (265)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Assessment of U = U knowledge and influencing factors among the population in Henan Province China based on an internet-based survey

Scientific Reports
This study evaluates the level of knowledge and the influencing factors related to the U = U (undetectable = untransmittable) concept among residents of Henan Province, China, using an online questionnaire.
Bowen Zhao, Yuan Hu, Qiongqiong Huang, Jialing Peng, Ruiling Li   +4 more
doaj   +1 more source

Guided Decision Tree: A Tool to Interactively Create Decision Trees Through Visualization of Subsequent LDA Diagrams

Applied Sciences
Decision trees are a widely used machine learning technique due to their ease of interpretation and construction. This method allows domain experts to learn from raw data, but they cannot include their prior knowledge in the analysis due to its automatic
Miguel A. Mohedano-Munoz, Laura Raya, Alberto Sanchez   +2 more
doaj   +1 more source

Weighted approximations for Studentized $U$-statistics

Brazilian Journal of Probability and Statistics, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Management and outcomes of women with placenta accreta spectrum grade 3: an INOSS multicountry multiperiod population-based study

BMC Pregnancy and Childbirth
Background Management and outcomes in women with placenta accreta spectrum grade 3 are rarely reported from population-based studies. The objective of this study is to describe profiles, management, and outcomes, of women with placenta accreta spectrum ...
Anne Pinton, Sara Ornaghi, Marian Knight, Loïc Sentilhes, Serena Donati, Gilles Kayem, Catherine Deneux-Tharaux   +6 more
doaj   +1 more source

U-Statistics for Change under Alternatives

Journal of Multivariate Analysis, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The flexible Lomax-G family with estimation methods and applications in hydrology and biomedicine

Scientific Reports
In this article, we introduce and investigate a new family of continuous distributions, termed the new Lomax-G (NLx-G) family, constructed via a novel generator.
Tariq Iqbal, Fatimah M. Alghamdi, Abdulaziz S. Alghamdi, Farrukh Jamal, Ahmed Z. Afify   +4 more
doaj   +1 more source