Results 121 to 130 of about 563,530 (312)

Renewal theory for asymmetric $U$-statistics

open access: yesElectronic Journal of Probability, 2018
We extend a functional limit theorem for symmetric $U$-statistics [Miller and Sen, 1972] to asymmetric $U$-statistics, and use this to show some renewal theory results for asymmetric $U$-statistics. Some applications are given.
openaire   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

FDE-Testset: Comparing Matlab© Codes for Solving Fractional Differential Equations of Caputo Type

open access: yesFractal and Fractional
Fractional differential equations (FDEs) have attracted more and more attention in the last years; among them, equations of Caputo type allow for “more natural” initial conditions when the order is greater than one.
Luigi Brugnano   +3 more
doaj   +1 more source

Empirical Bernstein Inequalities for U-Statistics

open access: yes, 2010
International audienceWe present original empirical Bernstein inequalities for U-statistics with bounded symmetric kernels q. They are expressed with respect to empirical estimates of either the variance of q or the conditional variance that appears in ...
Anthoine, Sandrine   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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