Results 141 to 150 of about 569,923 (314)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The flexible Lomax-G family with estimation methods and applications in hydrology and biomedicine

Scientific Reports
In this article, we introduce and investigate a new family of continuous distributions, termed the new Lomax-G (NLx-G) family, constructed via a novel generator.
Tariq Iqbal, Fatimah M. Alghamdi, Abdulaziz S. Alghamdi, Farrukh Jamal, Ahmed Z. Afify   +4 more
doaj   +1 more source

Decoupling and Khintchine's Inequalities for $U$-Statistics [PDF]

, 1992
Víctor Peña
openalex   +1 more source

A High-dimensional Convergence Theorem for U-statistics with Applications to Kernel-based Testing [PDF]

, 2023
Kevin H. Huang, Xing Liu, A. Duncan, Axel Gandy   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Sub-Bernoulli Functions, Moment Inequalities and Strong Laws for Nonnegative and symmetrized U-Statistics [PDF]

, 1999
Cun-Hui Zhang
openalex   +1 more source

$U$-statistics on bipartite exchangeable networks

, 2021
Tâm Le Minh
openalex   +1 more source

Semi-Supervised U-statistics

Semi-supervised datasets are ubiquitous across diverse domains where obtaining fully labeled data is costly or time-consuming. The prevalence of such datasets has consistently driven the demand for new tools and methods that exploit the potential of unlabeled data.
Kim, Ilmun, Wasserman, Larry, Balakrishnan, Sivaraman, Neykov, Matey   +3 more
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Rates of convergence for U-Statistics with varying kernels [PDF]

, 1980
N. C. Weber
openalex   +1 more source