Results 191 to 200 of about 2,406,899 (290)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Utilization of Critical Care U/S Imaging Tools for Assessment of Cardio-pulmonary Complications in Extracorporeal Circulatory Support in Patients Post Cardiac Surgery and ECMO. [PDF]

J Saudi Heart Assoc
Ragab MA, Mikhael SF, Elhadidy AE, Abdelmoneim IA, Al Faraidy KA, Alhusil AI, Abdelazeem MS, Fahmy A, Yacoub SH, Samter FA.   +9 more
europepmc   +1 more source

Observations of volatile organic and sulfur compounds in ambient air and health risk assessment near a paper mill in rural Idaho, U. S. A. [PDF]

Atmos Pollut Res, 2020
Scott PS, Andrew JP, Bundy BA, Grimm BK, Hamann MA, Ketcherside DT, Li J, Manangquil MY, Nuñez LA, Pittman DL, Rivero-Zevallos A, Uhlorn R, Johnston NAC.   +12 more
europepmc   +1 more source

Sebastian Schaar, Wahrnehmungen des Weltkrieges. Selbstzeugnisse Königlich Sächsischer Offiziere 1914 bis 1918, Paderborn [u. a.]: Schöningh 2014, VII, 333 S. (= Zeitalter der Weltkriege, 11), EUR 39,90 [ISBN 978-3-506-77998-4] [PDF]

, 2016
Marcus von Salisch
openalex   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study. [PDF]

Front Nutr
Yang S, Liao K, Zhou L, Zhang S, Wu J.
europepmc   +1 more source

Comparing textbook outcomes among patients undergoing surgery for cancer at U. S. News & World Report ranked hospitals. [PDF]

J Surg Oncol, 2020
Mehta R, Tsilimigras DI, Paredes AZ, Sahara K, Moro A, Farooq A, White S, Ejaz A, Tsung A, Dillhoff M, Cloyd JM, Pawlik TM.   +11 more
europepmc   +1 more source

Insights Into CO2 Loss, pH Effects, and Tafel Kinetics in Ni Single Atom‐Driven Bicarbonate Electroreduction

Advanced Science, EarlyView.
Selective CO formation in bicarbonate electrolysis is achieved by retaining reactive CO2 and tuning pH, while the competing hydrogen evolution reaction occurs at the interface. The rate‐determining step couples the chemical equilibrium of bicarbonate/CO2 with electrochemical charge transfer, offering insight into optimizing reaction conditions for ...
Lin Li, Yi‐Jie Kong, Ting Zhang, Xu Han, Kristine Aalestrup, Steen Uttrup Pedersen, Xin‐Ming Hu, Kim Daasbjerg   +7 more
wiley   +1 more source

Early diagnosis of impending rupture uterus during U/S: A case report. [PDF]

Int J Surg Case Rep
Parviz S, Deldar Pasikhani M, KHazardoost S, Malek M, Zamani N.   +4 more
europepmc   +1 more source

The U. S. Department of Veterans Affairs (VA) as a model for stronger public health infrastructure to combat HCV and other infectious diseases and reduce disparities. [PDF]

EClinicalMedicine, 2020
McGinnis KA, Suffoletto MS.
europepmc   +1 more source