Results 31 to 40 of about 2,406,899 (290)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Parlamentary elections in the District of Berane in 1920 and 1923 [PDF]
Zbornik Radova Filozofskog Fakulteta u Prištini, 2015 The lack of more significant political tradition due to the fact that Berane and the area of Donji Vasojevici were liberated from the Ottoman authorities in 1912, which lasted for many centuries, as well as the fact that only three years later a two-year
Virijević Vladan R. +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Parliamentary elections in the srez of Berane in 1925 and 1927 [PDF]
Zbornik Radova Filozofskog Fakulteta u Prištini, 2015 During the second half of the 20s in the last century political circumstances in Berane and its narrow gravitational area were known by constant rivalry between two civil political parties where the National Radical Party and the Yugoslav Democratic ...
Virijević Vladan R. +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Calibrated dilatometer exercise to probe thermoplastic properties of coal in pressurized CO2
International Journal of Coal Science & Technology, 2017 This research was aimed at testing a hypothesis, that at elevated CO2 pressure coal can soften at temperatures well below those obtained in the presence of other gases.
Vyacheslav N. Romanov +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Testing of Malting Barley - Variety Bojos.
Kvasný průmysl, 2006 The pilot plant and full-scale trials were made with malts from barley varieties Bojos and Tolar.The wort and beer were analysed to find out whether Tolar variety could be substitute for Bojos variety.
Petr KOFROŇ +3 more
doaj +1 more source
Tạp chí Khoa học Đại học Cần Thơ, 2023 Nghiên cứu được tiến hành nhằm ước lượng khả năng hấp thụ CO2 của rừng tràm (Melaleuca cajuputi Powell) tại Vườn Quốc gia U Minh Hạ, tỉnh Cà Mau. Số liệu được thu thập qua 12 ô tiêu chuẩn theo các độ dày than bùn: T (cm) < 40, T (cm) = 40 - 70, T (cm) =
Trần Quốc Khải +3 more
doaj +1 more source