Results 121 to 130 of about 15,754,334 (318)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

P114 | FACTORS INFLUENCING THE REGIMEN CHOICE FOR FIRST-LINE THERAPY IN CHRONIC LYMPHOCYTIC LEUKEMIA: THE FIRST-CLL STUDY

Haematologica
Treatment options for patients with chronic lymphocytic leukemia (CLL) have significantly increased over the years, and different first-line chemo-free regimens are now available.
F. Perutelli, M. Arata, M.C. Montalbano, R. Minuto, M. Nicolosi, S. Pepe, M. Deodato, E. Fioribello, A. Ferrario, E. Boccellato, R. Moia, M. Bullo, D. Gottardi, M. Foglietta, C. Salvetti, R. Freilone, G. Gaidano, M. Coscia, A.M. Frustaci, F.R. Mauro, B. Bruno, C. Vitale   +21 more
doaj  

Pharmacists as immunizers to Improve coverage and provider/recipient satisfaction: A prospective, Controlled Community Embedded Study with vaccineS with low coverage rates (the Improve ACCESS Study): Study summary and anticipated significance [PDF]

Canadian Pharmacists Journal / Revue des Pharmaciens du Canada, 2020
Jennifer E. Isenor, Melissa S. Kervin, Donna M. Halperin, Joanne Langley, Julie A. Bettinger, Karina A. Top, Fawziah Lalji, Kathryn Slayter, Janusz Kaczorowski, Susan K. Bowles, Nancy M. Waite, Scott A. Halperin, Beth Taylor, Shelly McNeil   +13 more
openaire   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease.

Brain : a journal of neurology, 2009
R. C. Helmich, M. Hallett, G. Deuschl, I. Toni, B. Bloem, N. Granger, H. Blamires, R. J. M. Franklin, N. D. Jeffery, V. Failli, M. A. Kopp, C. Gericke, P. Martus, S. Klingbeil, B. Brommer, I. Laginha, Y. Chen, M. DeVivo, U. Dirnagl, J. Schwab, M. Sashindranath, E. Sales, M. Daglas, R. Freeman, A. L. Samson, E. Cops, S. Beckham, A. Galle, C. Mclean, C. Morganti-Kossmann, J. V. Rosenfeld, R. Madani, J. Vassalli, Enming J Su, D. A. Lawrence, R. Medcalf, M. Starkey, C. Bleul, B. Zörner, N. T. Lindau, T. Mueggler, M. Rudin, M. Schwab, T. Doeppner, I. Młynarczuk-Biały, U. Kuckelkorn, B. Kaltwasser, J. Herz, M. R. Hasan, D. Hermann, M. Bähr, H. Sakata, P. Narasimhan, K. Niizuma, C. Maier, T. Wakai, P. H. Chan, M. M. Helmy, E. Ruusuvuori, P. V. Watkins, J. Voipio, P. Kanold, K. Kaila, E. Butti, M. Bacigaluppi, S. Rossi, M. Cambiaghi, M. Bari, A. C. Silla, E. Brambilla, A. Musella, R. de Ceglia, L. Teneud, V. De Chiara, P. D 'adamo, J. García-Verdugo, G. Comi, L. Muzio, A. Quattrini, L. Leocani, M. Maccarrone, D. Centonze, G. Martino, K. Sathe, W. Maetzler, J. D. Lang, R. B. Mounsey, C. Fleckenstein, H. L. Martin, C. Schulte, S. Mustafa, M. Synofzik, Z. Vukovic, S. Itohara, D. Berg, P. Teismann, C. Scherfler, K. Seppi, K. J. Mair, E. Donnemiller, I. Virgolini, G. Wenning, W. Poewe, L. Tönges, T. Frank, L. Tatenhorst, K. Saal, J. Koch, É. Szegõ, Jochen H Weishaupt, P. Lingor, J. Kończak, A. Sciutti, L. Avanzino, V. Squeri, M. Gori, L. Masia, G. Abbruzzese, G. Sandini, H. Tsuji, T. Arai, F. Kametani, T. Nonaka, M. Yamashita, M. Suzukake, M. Hosokawa, M. Yoshida, H. Hatsuta, M. Takao, Y. Saito, S. Murayama, H. Akiyama, M. Hasegawa, D. M. A. Mann, A. Tamaoka, D. S. Pitceathly, C. Smith, C. Fratter, C. Alston, L. He, K. Craig, E. Blakely, J. Evans, J. Taylor, Z. Shabbir, M. Deschauer, U. Pohl, M. Roberts, M. C. Jackson, C. Halfpenny, P. Turnpenny, P. W. Lunt, M. Hanna, A. Schaefer, R. Mcfarland, R. Horvath, P. Chinnery, D. Turnbull, J. Poulton, R. Taylor, G. Gorman, D. Ronchi, C. Garone, A. Bordoni, P. G. Rios, S. E. Calvo, M. Ripolone, M. Ranieri, M. Rizzuti, L. Villa, F. Magri, S. Corti, N. Bresolin, V. Mootha, M. Moggio, S. Dimauro, G. Comi, M. Sciacco, D. Cazzoli, R. Müri, R. Schumacher, S. von Arx, S. Chaves, K. Gutbrod, S. Bohlhalter, D. Bauer, T. Vanbellingen, M. Bertschi, S. Kipfer, C. R. Rosenthal, C. Kennard, C. Bassetti, T. Nyffeler, Brain   +193 more
semanticscholar   +1 more source

DP078 | DISEASE MONITORING BY 8-COLOR FLOW CYTOMETRY ON PERIPHERAL BLOOD AT DIAGNOSIS OF MANTLE CELL LYMPHOMA IN THE PROSPECTIVE FIL VR-BAC STUDY

Haematologica
Assessment of minimal residual disease (MRD) in peripheral blood (PB) at the time of diagnosis may be clinically informative in patients with mantle cell lymphoma (MCL).
S. Gambino, O. Perbellini, M. Galasso, I. Giaretta, A. Bravin, M.E. Carazzolo, M.T. Scupoli, M.C. Tisi, A. Merli, C. Rusconi, C. Castellino, V.R. Zilioli, F. Piazza, A. Re, S. Hohaus, F.G. Rossi, A.J.M. Ferreri, C. Patti, M. Balzarotti, J. Olivieri, P.L. Zinzani, B. Bianchi, G. Loseto, G. Musuraca, M. Spina, S.V. Usai, P.M. Stefani, C. Stelitano, C. Visco   +28 more
doaj  

Algebraic realisation of three fermion generations with $$S_3$$ S 3 family and unbroken gauge symmetry from $$\mathbb {C}\ell (8)$$ C ℓ ( 8 )

European Physical Journal C: Particles and Fields
Building on previous work, we extend an algebraic realisation of three fermion generations within the complex Clifford algebra $$\mathbb {C}\ell (8)$$ C ℓ ( 8 ) by incorporating a $$U(1)_{em}$$ U ( 1 ) em gauge symmetry. The algebra $$\mathbb {C}\ell (8)$
Liam Gourlay, Niels Gresnigt
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source