Results 191 to 200 of about 3,429,300 (308)
Identification of E3 Ubiquitin Ligases Associated with Survival in Soft Tissue Sarcomas. [PDF]
Int J Mol SciBender Z, Beird HC, Larsen P, Coombs GS.
europepmc +1 more source
Advanced Science, EarlyView.Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He +10 more
wiley +1 more source
E3 Ligases and Deubiquitinases in Controlling High-Mobility Group Box (HMGB) Protein Functions. [PDF]
Int J Mol SciChikhirzhina EV +2 more
europepmc +1 more source
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, EarlyView.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
Role of E3 Ubiquitin Ligases in Oligodendrocyte Health and Disease. [PDF]
ASN NeuroMabb AM, Pyaram DN, Samanta J.
europepmc +1 more source
Advanced Science, EarlyView.Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source