Results 231 to 240 of about 80,046 (337)

Interaction of U‐box‐type ubiquitin‐protein ligases (E3s) with molecular chaperones [PDF]

, 2004
Shigetsugu Hatakeyama, Masaki Matsumoto, Masayoshi Yada, Keiichi I. Nakayama   +3 more
openalex   +1 more source

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib‐Resistant Lung Cancer Therapy

Advanced Science, EarlyView.
In this study, an EGFR lipoSM PROTACs (GM‐protac), which can achieve efficient EGFR degradation and HDACi delivery, is developed. It is found that GM‐protac can both block EGFR‐dependent pathways and bypass the HDAC signaling pathway. Meanwhile, both display obvious tumor inhibition with negligible toxicity in EGFR‐TKI‐resistant lung cancer animal ...
Dongyuan Wang, Yajing Liu, Ying Chen, Chuan Dai, Wenzhu Hu, Jinyan Han, Zigang Li, Feng Yin, Yu Zhang, Chen Shi   +9 more
wiley   +1 more source

Research advancements regarding the relationship between FBXO2 and malignant tumors (Review). [PDF]

Mol Med Rep
Zhang J, Yang J, Zhang X, Yuan Y, Sun S, Zhang S, He J.   +6 more
europepmc   +1 more source

Regulation of Ubiquitin Protein Ligase Activity in c-Cbl by Phosphorylation-induced Conformational Change and Constitutive Activation by Tyrosine to Glutamate Point Mutations [PDF]

, 2004
C. Kenneth Kassenbrock, Steven M. Anderson   +1 more
openalex   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization. [PDF]

Sci Adv
Perrard J, Gao K, Ring K, Smith S.
europepmc   +1 more source

Marker Metabolite‐Based Multi‐Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus

Advanced Science, EarlyView.
Marker metabolite‐based multi‐omics (genome, transcriptome, and metabolome) analysis is conducted firstly to unravel the genetic basis of thousand seed weight (TSW) in Brassica napus. The released metabolite‐QTL‐gene network represents a valuable genetic resource, and the newly validated BnaTGA6 is a promising target for the improvement of TSW in ...
Long Li, Zhitao Tian, Xiaowei Wu, Zengdong Tan, Xu Han, Yuyan Xiang, Jie Chen, Hu Zhao, Wei Chen, Liang Guo, Xuan Yao   +10 more
wiley   +1 more source

Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes

Angewandte Chemie, EarlyView.
Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi, Chong Zhang, William A. Donald   +2 more
wiley   +2 more sources

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu, Chiharu Nakasu, Yu Saito, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Hiroki Teraoku, Mitsuo Shimada   +7 more
wiley   +1 more source

Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase. [PDF]

PLoS Pathog
Liu S, He C, Zhang Y, Liu S, Chen TT, Li C, Chen D, Ouyang S, Song L, Fu J, Luo ZQ.   +10 more
europepmc   +1 more source