Results 261 to 270 of about 81,275 (289)

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain. [PDF]

Sci Rep
Liu H, Francis L, Dagley LF, Cobbold SA, Webb AI, Komander D, Villadangos JA, Mintern JD.   +7 more
europepmc   +1 more source

Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders. [PDF]

RSC Chem Biol
Tsuji K, Huang X, Miyamoto M, Sukegawa S, Yokoo H, Takeuchi H, Demizu Y, Tamamura H.   +7 more
europepmc   +1 more source

Loss of Tripartite Motif–Containing Protein 21 and UVB‐Induced Systemic Inflammation by Regulating DNA‐Sensing Pathways

Arthritis &Rheumatology, EarlyView.
Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard Ainsworth, Trinitee Oliver, Gabriela De Los Santos, David Gibb, Jessica Carriere, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies   +17 more
wiley   +1 more source

Protective Effects of Quinic Acid Against Disuse-Induced Skeletal Muscle Atrophy via Regulation of Inflammation and Oxidative Stress. [PDF]

Foods
Kim MB, Lee H, Kang J, Kim B, Hwang JK.
europepmc   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, EarlyView.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

The E3 ligase MEX3B forms a tripartite complex with <i>Rest</i> and <i>Hotair</i> to determine the proliferative capacity of neural progenitor cells. [PDF]

Open Biol
Garg K, Sharma G, Samaddar S, Banerjee S.   +3 more
europepmc   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, EarlyView.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Research advancements regarding the relationship between FBXO2 and malignant tumors (Review). [PDF]

Mol Med Rep
Zhang J, Yang J, Zhang X, Yuan Y, Sun S, Zhang S, He J.   +6 more
europepmc   +1 more source

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

How <i>Shigella</i> tackles host defences. [PDF]

Elife
Huang Y, Thurston TLM.
europepmc   +1 more source