Results 271 to 280 of about 81,275 (289)

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest. [PDF]

Clin Exp Med
Lin J, Chen F, Tang H, Cai X, Huang M, Liang R, Kang R, Tang D, Liu J.   +8 more
europepmc   +1 more source

Antioxidant Activity and Potential Cholesterol Modulating Effect of Punica granatum L. Peel Hydroethanolic Extract

Chemistry &Biodiversity, EarlyView.
Punica granatum peel extract is rich in phenolic compounds, exhibits strong antioxidant activity, and modulates the expression of PCSK9 and LDL receptors. Collectively, these findings suggest a potential cardioprotective effect of the extract. ABSTRACT Lipoprotein metabolism is regulated by several key proteins, notably proprotein convertase subtilisin/
Raja Chaaba, Amel Nakbi, Ilaria Rossi, Hanen Jrah, Zahra Amri, Nicola Ferri, Sonia Hammami, Stefano Dall'Acqua, Mohamed Hammami, Sounira Mehri   +9 more
wiley   +1 more source

Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization. [PDF]

Sci Adv
Perrard J, Gao K, Ring K, Smith S.
europepmc   +1 more source

SUMO-targeted Ubiquitin Ligases as crucial mediators of protein homeostasis in Candida glabrata

Dipika Gupta, Renu Shukla, Krishnaveni Mishra   +2 more
openalex   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase. [PDF]

PLoS Pathog
Liu S, He C, Zhang Y, Liu S, Chen TT, Li C, Chen D, Ouyang S, Song L, Fu J, Luo ZQ.   +10 more
europepmc   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Pellino ubiquitin ligases: double-edged swords in hematologic malignancies-from oncogenic stabilizers to therapeutic vulnerabilities. [PDF]

J Cancer Res Clin Oncol
Yang M, Li Y, Wang J.
europepmc   +1 more source

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

ChemMedChem, EarlyView.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source