Results 281 to 289 of about 81,275 (289)

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression. [PDF]

Mol Biomed
Wen H, Maheremu M, Zhang K, Bao L, Luo M, Zhang Y, Liao Y, Zhou M, Wu C, Lv S, Qiu X, Wei Q.   +11 more
europepmc   +1 more source

Toward Anti‐Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma‐Associated Herpesvirus Latency‐Associated Nuclear Antigen

ChemMedChem, EarlyView.
It is attempted to employ proteolysis‐targeting chimeras‐based targeted protein degradation to the viral protein “Latency‐associated Nuclear Antigen” from Kaposi's sarcoma‐associated herpesvirus. While ternary complex formation is detected via native mass spectrometry, protein degradation is not observed, presumably due to insufficient permeability ...
Aylin Berwanger, Saskia Catherina Stein, Sarah Brandner, Andreas Martin Kany, Sebastian Heinz, Brigitta Loretz, Claus‐Michael Lehr, Anna Katharina Herta Hirsch, Frederik Lermyte, Thomas Friedrich Schulz, Martin Empting   +10 more
wiley   +1 more source

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation. [PDF]

Nat Commun
Vrentzou A, Leidner F, Schmidt CC, Grubmüller H, Stein A.   +4 more
europepmc   +1 more source

The Roles of E3 Ubiquitin Ligases in Cerebral Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Li M, Yu X, Liu Q, Fang Z, Wang H.
europepmc   +1 more source

Depurination of sarcin/ricin loop 25S rRNA is signaled through the small ribosomal subunit during translation. [PDF]

RNA
Prashar T, Hudak KA.
europepmc   +1 more source

A LjBAK1-associated E3 ubiquitin ligase, LjPUB7, negatively regulates early symbiosis by targeting NFRs. [PDF]

BMC Plant Biol
Feng Y, Zou Z, Liu C, Zhang D, Wang Y, Ma Y, Cao Y, Wu P.   +7 more
europepmc   +1 more source

Targeted protein degradation of HSP90 and associated proteins for cancer therapy <i>via</i> PROTACs and beyond. [PDF]

RSC Med Chem
Kumar G, Tyagi G, Monga V.
europepmc   +1 more source

Ubiquitin-Conjugating Enzyme Positively Regulates Salicylic Acid and Jasmonic Acid Biosynthesis to Confer Broad-Spectrum Antiviral Resistance in <i>Nicotiana benthamiana</i>. [PDF]

Plants (Basel)
Zhang X, Chen Z, Jiang S, Xie L, Fan J, Hu N, Zhang X.   +6 more
europepmc   +1 more source