Results 321 to 330 of about 519,123 (352)
Some of the next articles are maybe not open access.
Targeting the monocytic ubiquitin system with extracellular ubiquitin
Immunology & Cell Biology, 2006Recent findings suggest that extracellular ubiquitin has pleiotropic effects on host defence mechanisms, but its cellular mechanism of action is not yet understood. Using fluorescence and in vivo confocal microscopy, we observed uptake of N‐terminal fluorescein‐labelled ubiquitin into human PBMC and MonoMac 6 cells. Immunoblotting experiments indicated
Matthias, Majetschak +2 more
openaire +2 more sources
Ubiquitin adenylate: structure and role in ubiquitin activation
Biochemistry, 1983The acid precipitate of the ubiquitin activating enzyme after reaction with ATP and ubiquitin contains one enzyme equivalent of ubiquitin adenylate in which the carboxyl-terminal glycine of ubiquitin and AMP are in an acyl-phosphate linkage. The recovered ubiquitin adenylate has the catalytic properties proposed for it as a reaction intermediate. Thus,
A L, Haas, J V, Warms, I A, Rose
openaire +2 more sources
A ubiquitin and ubiquitin‐like protein spectral library
PROTEOMICS, 2010AbstractWe have developed and validated a ubiquitin (Ub) and ubiquitin‐like protein (Ubl) spectral library, consisting of 467 consensus spectra (320 unique peptides derived from autophagy‐related protein 8, F‐adjacent transcript 10, interferon‐stimulated gene 15 kDa protein, neural precursor cell expressed developmentally down‐regulated protein 8 ...
Srikumar, Tharan +3 more
openaire +3 more sources
Ubiquitin and ubiquitin-like proteins as multifunctional signals
Nature Reviews Molecular Cell Biology, 2005Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins.
Rebecca L, Welchman +2 more
exaly +3 more sources
Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains
2012Since its discovery over three decades ago, it has become abundantly clear that the ubiquitin (Ub) system is a quintessential feature of all aspects of eukaryotic biology. At the heart of the system lies the conjugation and deconjugation of Ub and Ub-like (Ubls) proteins to proteins or lipids drastically altering the biochemistry of the targeted ...
A Maxwell, Burroughs +2 more
openaire +2 more sources
Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases
2019Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
openaire +2 more sources
An expanded lexicon for the ubiquitin code
Nature Reviews Molecular Cell Biology, 2022Ivan Đikić, Brenda A Schulman
exaly