Results 321 to 330 of about 574,104 (383)

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction

Angewandte Chemie, EarlyView.
Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high‐yielding, scalable reaction that proceeds under mild, catalyst‐free conditions. It operates via a multi‐step domino reaction mechanism, where an in situ‐formed pyrrolidinium salt functions as a HBD organoautocatalyst.
Volker Klein, Florian Schuster, Jonas Amthor, Harald Maid, Prabhakar Bijalwan, Fahmi Himo, Stefano Santoro, Svetlana B. Tsogoeva   +7 more
wiley   +2 more sources

Ubiquitin-specific peptidase 20 affects immune cell infiltration by regulating prostaglandin E2 on intraperitoneal metastasis model of colorectal cancer. [PDF]

Transl Cancer Res
Hua Y, Ma X, Zhao X, Wei X, Mu X, Wang B, Yuan X.   +6 more
europepmc   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Small Molecule‐Induced Alterations of Protein Polyubiquitination Revealed by Mass‐Spectrometric Ubiquitome Analysis

Angewandte Chemie, EarlyView.
To monitor small molecule‐induced changes in protein polyubiquitination in an unbiased manner, we employ enrichment through tandem ubiquitin binding entities coupled to LC‐MS/MS analysis (TUBE‐MS). By applying the workflow to PROTAC, p97‐ and deubiquitinase‐inhibitor treatment of cells, we demonstrate its broad applicability and reveal the induction of
Siska Führer, Kai Gallant, Farnusch Kaschani, Markus Kaiser, Petra Janning, Herbert Waldmann, Malte Gersch   +6 more
wiley   +2 more sources

A Brief Overview of the Epigenetic Regulatory Mechanisms in Plants. [PDF]

Int J Mol Sci
Tresas T, Isaioglou I, Roussis A, Haralampidis K.   +3 more
europepmc   +1 more source

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex. [PDF]

Sci Rep
Swanson MEV, Tan AYS, Tippett LJ, Turner CP, Curtis MA, Scotter EL, Lashuel HA, Dragunow M, Faull RLM, Murray HC, Singh-Bains MK.   +10 more
europepmc   +1 more source

Linear Ubiquitination of Hemocyanin Mediated by LUBEL Regulates Innate Immunity in <i>Penaeus vannamei</i>. [PDF]

Int J Mol Sci
Zhang X, Zhang H, Zhang Y, Lin Z.
europepmc   +1 more source

Ubiquitin-activating enzyme1 (TgUAE1) acts as a key regulator of Toxoplasma gondii lytic cycle and homeostasis. [PDF]

Commun Biol
Zhou QX, Lu DQ, Tian SY, Lv Y, Chen MW, Tian X, Wu YT, Luo FJ, Tan F, Mou YN.   +9 more
europepmc   +1 more source

Identification of RING E3 pseudoligases in the TRIM protein family. [PDF]

Nat Commun
Dudley-Fraser J, Esposito D, McPhie KA, Morley-Williams C, Auchynnikava T, Rittinger K.   +5 more
europepmc   +1 more source