An expanded lexicon for the ubiquitin code
Nature Reviews Molecular Cell Biology, 2022 Recent studies have expanded our understanding of the mechanisms and functions of ubiquitylation. Pathogens rewrite ubiquitylation to promote infection through unconventional ubiquitylation involving lipids and sugars, and structural studies have ...
I. Dikič, B. Schulman
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Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Nature Reviews Molecular Cell Biology, 2016 L. Buetow, Danny T. Huang
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Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities
Cell Death and Differentiation, 2021 Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline.
Marlene Schmidt +3 more
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E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang +3 more
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Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes
Journal of Cell Biology, 2004 Ubiquitination directs the sorting of cell surface receptors and other integral membrane proteins into the multivesicular body (MVB) pathway. Cargo proteins are subsequently deubiquitinated before their enclosure within MVB vesicles.
Natalie Luhtala, G. Odorizzi
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A contribution to breast cancer cell proteomics: detection of new sequences [PDF]
, 2002 Ductal infiltrating carcinoma (DIC) of the breast is the most common and potentially aggressive form of cancer. Knowledge of proteomic profiles, attained both in vivo and in vitro, is fundamental to acquire as much information as possible on the proteins
Basiric\uf2, L. +5 more
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Ubiquitin ligases in oncogenic transformation and cancer therapy
Nature Reviews Cancer, 2017 D. Senft, Jianfei Qi, Z. Ronai
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Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior [PDF]
, 2002 In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation.
Ceriani, Maria Fernanda +5 more
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Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis [PDF]
, 2007 Background The Oncomine™ database is an online collection of microarrays from various sources, usually cancer-related, and contains many "multi-arrays" (collections of analyzed microarrays, in a single study).
Giguère Vincent, Wilson Brian J
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Proteome analysis of human substantia nigra in Parkinson's disease [PDF]
, 2004 Protein expression has been compared in human substantia nigra specimens from Parkinson's disease (PD) patients and from controls, and 44 proteins expressed in this midbrain region were identified by peptide mass fingerprinting.
Basso +45 more
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