Results 11 to 20 of about 3,159 (85)

The comparative proteomics of ubiquitination in mouse [PDF]

, 2003
Ubiquitination is a common posttranslational modification in eukaryotic cells, influencing many fundamental cellular processes. Defects in ubiquitination and the processes it mediates are involved in many human disease states.
?, ?, Semple, Colin A M; id_orcid
core   +2 more sources

Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology

, 2014
Autosomal dominant osteopetrosis type II (ADO II) is a rare, heritable bone disorder characterized by a high bone mass and insufficient osteoclast activity. Mutations in the CLCN7 gene have been reported to cause ADO II.
de Vernejoul M.C., Collet C, Schiltz C, Olaso R, Baulard C, TETI, ANNA MARIA, Coudert AE, Del Fattore A   +7 more
core   +2 more sources

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells

, 2014
The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable at least in part to intracellular toxic oligomers of IAPP (islet amyloid polypeptide).
Butler, Peter C, Costes, Safia, Rivera, Jacqueline F, Gurlo, Tatyana   +3 more
core   +1 more source

β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons.

, 2013
Several lines of evidence have supported the potential involvement of metal ions in the etiology of Alzheimer's Disease (AD). However, the molecular mechanisms underlying this interaction are still partially unknown. Previous work from our laboratory has
Zatta P., Bolognin, Silvia, BUFFELLI, Mario Rosario, LORENZETTO, Erika, VALENTI, Maria Teresa   +4 more
core   +1 more source

マウスの舌および軟口蓋における味覚受容器の発生過程　受容器の発現時期と味覚機能発現について [PDF]

, 2011
味蕾の発生について、HE染色した切片から胎生期と出生後について時系列で形態学的に観察後、分子生物学的手法を用いて、マウス味覚受容器の機能発現を胎生期から出生後まで時系列的に調べた。胎生11日以降において、甘味、旨味の認識に関わるT1RsファミリーのmRNAが発現した。味蕾の形成は胎生期から始まり、味蕾形成に関わる抗PGP9.5抗体陽性細胞の出現、味覚機能タンパク質(α-ガストデューシン)と味覚受容体(mGluR)は、その発現が開始する順序は、軟口蓋、茸状乳頭、有郭乳頭であった ...
12526, 加川, 千鶴世, 宗形, 芳英, 12527, 大須賀, 謙二, 12524, 12525, 鈴木, 康生   +7 more
core   +1 more source

Retinoic Acid-inducible Gene-I Increases Interferon-stimulated Gene 15 Expression in Human Renal Proximal Tubule Epithelial Cells. [PDF]

In Vivo
Tachizaki M, Kawaguchi S, Tanaka H, Imaizumi T.   +3 more
europepmc   +1 more source

Blood-based biomarkers GFAP/UCH-L1 for the diagnosis of mild traumatic brain injury (mTBI): a single-center implementation experience. [PDF]

Eur J Trauma Emerg Surg
Maegele M, Breidenbach L, Kaufmann J, Keles Y, Uhl E, Schroeer P.   +5 more
europepmc   +1 more source

Case report: Onychopapilloma in a patient with BAP1 tumor predisposition syndrome-a useful clinical marker? [PDF]

Fam Cancer
Sjøstrøm E, Ahlborn LB, Eliesen EV, Wadt K, Lei U, Byrjalsen A.   +5 more
europepmc   +1 more source

Study protocol for investigating real-world implementation of a combined glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) blood test in the management of adult mild traumatic brain injury in a single-centre European emergency department: the IMPACTS-BRAINI study. [PDF]

BMJ Open
Lagares A, Maldonado M, Baciu A, Tosi L, Loynaz C, Martinez S, Castaño León AM, Hernández-Sánchez J, García Barrio N, de la Cruz J, Sánchez S, Lopez Jiménez A, Cueto-Felgueroso C, Carrasco L, Marquez E, María Fernández Del Pozo A, Amil C, Arias A, Mejan O.   +18 more
europepmc   +1 more source

Ubiquitin-Specific Protease 49 Interacts with Bax to Modulate Apoptosis. [PDF]

Int J Mol Sci
Choi HS, Kim SY, Kim SR, Baek KH.
europepmc   +1 more source