A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors [PDF]
, 2008 International audienceG protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are major drug targets. Recent progress has shown that GPCRs are part of large protein complexes that regulate their activity.
Maurice, Pascal +12 more
core +2 more sources
International Journal of Molecular Sciences, 2020 Owing to a sessile lifestyle in nature, plants are routinely faced with diverse hostile environments such as various abiotic and biotic stresses, which lead to accumulation of free radicals in cells, cell damage, protein denaturation, etc., causing ...
Weigang Liu +8 more
semanticscholar +1 more source
Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism
Chemical Reviews, 2017 Ubiquitin-like proteins (Ubl’s) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions.
L. Cappadocia, C. Lima
semanticscholar +1 more source
Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
core +1 more source
Ubiquitin-mediated regulation of autophagy
Journal of Biomedical Sciences, 2019 Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis.
Ruey-Hwa Chen +2 more
semanticscholar +1 more source
Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking [PDF]
, 2013 The importance of epigenetic regulation has been increasingly recognized in the development of cancer. In this study, we investigated the impact of smoking, a major risk factor of lung cancer, on DNA methylation by comparing the genome-wide DNA ...
Guan Wang +7 more
core +2 more sources
Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
Front. Cell Dev. Biol., 2018 Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular quality control and recycling mechanisms that are responsible for cellular homeostasis in eukaryotes.
N. M. Kocaturk, D. Gozuacik
semanticscholar +1 more source
Cell Cycle Regulation in the Florida Red Tide Dinoflagellate, Karenia brevis [PDF]
, 2011 The dinoflagellate, Karenia brevis, produces harmful algal blooms in the Gulf of Mexico that cause extensive marine animal mortalities and human illness nearly annually.
Brunelle, Stephanie Alexandra
core +1 more source
, 2009 DNA-methylatie is een epigenetische modificatie. Dit type van modificaties verandert de genetische informatie zelf niet, maar wijzigt de laag erboven. Er worden chemische modificaties toegevoegd of gewijzigd op het DNA of de histonen (waarrond het DNA ...
Ongenaert, Maté
core +1 more source
Detection of ubiquityl-calmodulin conjugates with a novel high-molecular weight ubiquitylprotein-isopeptidase in rabbit tissues [PDF]
, 2010 The selective degradation of many proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved protein [1].
Jennissen, HP +3 more
core +3 more sources