Results 31 to 40 of about 28,161 (266)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Activities, context and ubiquitous computing [PDF]
Computer Communications, 2003 Context and context-awareness provides computing environments with the ability to usefully adapt the services or information they provide. It is the ability to implicitly sense and automatically derive the user needs that separates context-aware applications from traditionally designed applications, and this makes them more attentive, responsive, and ...
Paul Prekop, Mark Burnett
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
IEEE Access, 2020 For multiple transmitter-receiver pairs communication in a frequency-selective environment, typical power allocation method is the Iterative-Waterfilling (IW) algorithm.
Mingjun Dai +5 more
doaj +1 more source
UBIQUITOUS COMPUTING: A PRIMER
International Journal of Advances in Scientific Research and Engineering, 2018 Ubiquitous computing is an emerging research area which is due to the rapid evolution in smart devices, as well as tremendous advances in wireless networks and mobile computing. It is a technology, in which invisible computers are embedded and connected with all things enabling using computers anywhere at any time.
Sadiku, Matthew N. O. +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Investigating (re)current state-of-the-art in human activity recognition datasets
Frontiers in Computer Science, 2022 Many human activities consist of physical gestures that tend to be performed in certain sequences. Wearable inertial sensor data have as a consequence been employed to automatically detect human activities, lately predominantly with deep learning methods.
Marius Bock +4 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Internet of Things for Smart Spaces: A University Campus Case Study
Sensors, 2020 Advances in technology and data analysis provide rich opportunities for developing intelligent environments assisting their inhabitants, so-called smart environments or smart spaces.
Ekaterina Gilman +8 more
doaj +1 more source