Results 71 to 80 of about 7,495,371 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Brexit and the Anglosphere: an intra-industry trade opportunity for India? [PDF]

Eastern Journal of European Studies, 2020
The present paper outlines a functionalist approach to the complex “Brexit” phenomenon, exploring those opportunities that can be derived of it for third countries, unaware of the upheaval European scenario, as could be the case of India.
Francisco José CALDERÓN VÁZQUEZ, Vikesh CHANDNANI SUKHWANI, Pablo PODADERA RIVERA   +2 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Innovations in Journalism as Complex Interplay: Supportive and Obstructive Factors in International Comparison

Media and Communication
Where does innovation in journalism come from, how is it implemented, and what factors drive or hinder its development? Scholars have explored these questions from different perspectives for over two decades.
Klaus Meier, Michael Graßl, Jose Alberto García-Avilés, Dámaso Mondejar, Andy Kaltenbrunner, Renée Lugschitz, Colin Porlezza, Petra Mazzoni, Vinzenz Wyss, Mirco Saner   +9 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

PLUMBING THE BRAIN DRAIN OF SOUTH AFRICAN SOCIAL WORKERS MIGRATING TO THE UK: CHALLENGES FOR SOCIAL SERVICE PROVIDERS

Social Work/Maatskaplike Werk, 2006
This article reports research that was undertaken to uncover generalisations pertaining to the migration of South African social workers to the United Kingdom (UK).
Lambert K Engelbrecht
doaj   +1 more source

Spiritual writings and religious instruction [PDF]

, 2008
As soon as a would-be writer picked up the pen in this period, he (or just occasionally she) had to make a far-reaching decision: whether to write in English, Anglo-Norman or Latin. The answer would emerge from the intersection of the text's genre and of
Barratt, Alexandra
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Between Rhetoric and Reality: Consensus on the UK's Role in Union External Action Post-Brexit?

European Papers, 2018
(Series Information) European Papers - A Journal on Law and Integration, 2018 3(1), 465-466 | European Forum Highlight of 16 March 2018 | (Abstract) This Highlight compares the EU Commission's Draft Withdrawal Agreement with the UK's Draft Text for ...
Luigi Pedreschi
doaj   +1 more source