Results 91 to 100 of about 686,074 (269)

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

In Vivo Imaging of Glial Activation after Unilateral Labyrinthectomy in the Rat: A [18F]GE180-PET Study

Frontiers in Neurology, 2017
The functional relevance of reactive gliosis for recovery from acute unilateral vestibulopathy is unknown. In the present study, glial activation was visualized in vivo by [18F]GE180-PET in a rat model of unilateral labyrinthectomy (UL) and compared to ...
Andreas Zwergal, Andreas Zwergal, Lisa Günther, Matthias Brendel, Matthias Brendel, Roswitha Beck, Simon Lindner, Guoming Xiong, Eva Eilles, Marcus Unterrainer, Nathalie Lisa Albert, Sandra Becker-Bense, Sandra Becker-Bense, Thomas Brandt, Thomas Brandt, Sibylle Ziegler, Christian la Fougère, Christian la Fougère, Marianne Dieterich, Marianne Dieterich, Marianne Dieterich, Peter Bartenstein, Peter Bartenstein, Peter Bartenstein   +23 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Degradasi Larutan Pewarna Azo Tekstil Menggunakan Sistem Heterogenan O3, O3/UL, O3/TIO2/UL DAN O3/H2O2/UL [PDF]

, 2012
Rawatan larutan pewarna azo tekstil, Sumifix Supra Blue BRF 150% Gran (SSBBRF) melibatkan sistem yang berbeza, O3, O3/UL, O3/TiO2/UL dan O3/H2O2/UL telah dikaji.
Wan Azelee Wan Abu Bakar, Wan Abu Bakar, Aris AZ, Ali Razak, Azmi   +4 more
core   +1 more source

Bound Water as a Reinforcing Element for Ultra‐Strong Polyacrylamide

Advanced Science, EarlyView.
Rather than acting as a conventional plasticizer, bound water serves as a reinforcing element in polyacrylamide by constructing strong PAM–water–PAM hydrogen‐bond networks. This water‐mediated architecture delivers ultra‐high mechanical strength and exceptional flame resistance, redefining the role of water in polymer reinforcement.
Sirawit Pruksawan, Nannan Li, Zehuang Lin, Jianwei Zheng, Terence Jun En Loh, Yi Ting Chong, Junhua Kong, Xunan Hou, Xian Jun Loh, Chaobin He, FuKe Wang   +10 more
wiley   +1 more source

Meshless TL and UL approaches for large deformation analysis

, 2010
To accurately and effectively simulate large deformation is one of the major challenges in numerical modeling of metal forming. In this paper, an adaptive local meshless formulation based on the meshless shape functions and the local weak-form is ...
Gu, YuanTong, Yuan Tong Gu
core   +1 more source

Coordination‐Tuned Iridium Single‐Atom Nanozymes Boost Multienzyme Activity for Colorimetric Sensing

Advanced Science, EarlyView.
Breaking the coordination symmetry of Ir single‐atom sites through asymmetric Ir–N3S1 engineering tailors interfacial electron transfer, oxygen activation, and multienzyme‐like catalytic pathways. Operando spectroscopy and theoretical modeling uncover the atomic‐level origin of activity enhancement, providing a strategy for designing multifunctional ...
Tao Li, Xinyu Zhang, Jiashan Xia, Mengyu Wu, Cong Liu, Yapei Sun, Wanjiang Zhao, Min Qian, Wei Wang, Weixia Duan, Shangcheng Xu   +10 more
wiley   +1 more source

A Study on the Perception of Fear of Crime Among UL Lafayette Students

Research has constantly found that campus crime rates are relatively low compared to those in the surrounding areas. Many students still experience a meaningful level of fear of crime that significantly influences their daily routines and impacts their ...
Hasan, Md Rakibul
core  

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source