Results 71 to 80 of about 803,265 (414)

Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people.

Cochrane Database of Systematic Reviews, 2016
BACKGROUND Peptic ulcer disease is the cause of dyspepsia in about 10% of people. Ninety-five percent of duodenal and 70% of gastric ulcers are associated with Helicobacter pylori. Eradication of H.
A. Ford, K. Gurusamy, B. Delaney, D. Forman, P. Moayyedi   +4 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Invasive Candida krusei infection and Candida vasculitis of a leg ulcer in an immunocompetent patient: A case report

International Journal of Infectious Diseases, 2017
A 71 year old female Caucasian farmer without any known immunosuppression presented with a painful ulcer of her right lower leg after a trauma caused by a wood billet. There was no response to empirical antibacterial treatment.
Philipp Jud, Thomas Valentin, Sigrid Regauer, Thomas Gary, Gerald Hackl, Peter Rief, Marianne Brodmann, Franz Hafner   +7 more
doaj   +1 more source

Increased Mortality in Diabetic Foot Ulcer Patients: The Significance of Ulcer Type

Journal of Diabetes Research, 2016
Diabetic foot ulcer (DFU) patients have a greater than twofold increase in mortality compared with nonulcerated diabetic patients. We investigated (a) cause of death in DFU patients, (b) age at death, and (c) relationship between cause of death and ulcer
N. Chammas, R. Hill, M. Edmonds
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Traumatic ulcerative granuloma with stromal eosinophilia

Indian Journal of Dental Research, 2020
Oral ulcers constitute one of the most common chief complaints of patients attending any dental practice. The cause of oral mucosal ulceration is generally attributed to acute or chronic trauma from local factors. However, oral lesions may be the initial
Aashka Sethi, Akanksha Banga, Ritika Raja, Reema Raina   +3 more
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

EPUAP classification system for pressure ulcers: European reliability study [PDF]

, 2007
‘The definitive version is available at www3.interscience.wiley.com .' Copyright Blackwell PublishingPeer ...
Bates-Jensen B.M, Bennett R.G., Black J., Bours G.J., Collier M., Dealey C., Derre B., Donnelly J., European Pressure Ulcer Advisory Panel (EPUAP), Fletcher J., Guggenmoos-Holzmann I., Maklebust J., National Pressure Ulcer Advisory Panel., Polit D.F., Russell L., Sharp A., Witkowski J.A., Wound, Ostomy, and Continence Nurses Society (WOCN)   +17 more
core   +1 more source

Co-creation of a gender responsive TB intervention in Nigeria: a researcher-led collaborative study

BMC Health Services Research
Background In Nigeria, men constitute over half of the people notified with tuberculosis (TB), experience longer delays before reaching care, and are estimated to account for two thirds of people who miss out on care. The higher TB risk and burden in men
Chukwuebuka Ugwu, Oluwatoyosi Adekeye, Beate Ringwald, Rachael Thomson, Obioma Chijioke-Akaniro, Chukwuma Anyaike, S Bertel Squire, John Bimba, Tom Wingfield   +8 more
doaj   +1 more source

Use of platelet-rich plasma and modified nanofat grafting in infected ulcers: Technical refinements to improve regenerative and antimicrobial potential

Archives of Plastic Surgery, 2020
Background Surgical reconstruction of chronic wounds is often infeasible due to infection, comorbidities, or poor viability of local tissues. The aim of this study was to describe the authors’ technique for improving the regenerative and antimicrobial ...
Francesco Segreto, Giovanni Francesco Marangi, Carolina Nobile, Mario Alessandri-Bonetti, Chiara Gregorj, Vincenzo Cerbone, Marco Gratteri, Erika Caldaria, Maria Cristina Tirindelli, Paolo Persichetti   +9 more
doaj   +1 more source