Results 181 to 190 of about 730,197 (357)

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

A Systematic Review of the Cost-Effectiveness of Interventions for Chronic Wounds. [PDF]

Int Wound J
Marešová P, Randlová K, Režný L, Hruška J, Wolff-Winiski B, Dupin D, Kuča K.   +6 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report. [PDF]

In Vivo
Lin CC, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC.   +6 more
europepmc   +1 more source

IWGDF guidance on the diagnosis, prognosis and management of peripheral artery disease in patients with foot ulcers in diabetes

Diabetes/Metabolism Research Reviews, 2016
R. Hinchliffe, J. Brownrigg, J. Apelqvist, Edward J. Boyko, R. Fitridge, J. Mills, J. Reekers, C. P. Shearman, R. E. Zierler, N. Schaper   +9 more
semanticscholar   +1 more source

Ulcerative Duodenitis

Internal Medicine, 2021
Nakase, Hiroshi, Honzawa, Yusuke, Matsuura, Minoru   +2 more
openaire   +3 more sources

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Multilesional pyoderma gangrenosum is associated with longer healing times and higher rates of underlying comorbidities: A single-center prospective registry study

JAAD International, 2023
Hannah Zhao, BA, Arash Mostaghimi, MD, MPA, MPH, Jonathan M. Sisley, BS, Alex G. Ortega-Loayza, MD, MCR   +3 more
doaj   +1 more source

Mpox in a 49-year-old man with possible immune reconstitution inflammatory syndrome. [PDF]

CMAJ
Goto T, Maruno M, Sakamoto N.
europepmc   +1 more source

A shift in priority in diabetic foot care and research: 75% of foot ulcers are preventable

Diabetes/Metabolism Research Reviews, 2016
S. Bus, J. Netten
semanticscholar   +1 more source