Results 51 to 60 of about 730,197 (357)
Diabetic foot disease and oedema [PDF]
, 2013 Diabetic foot ulcers (DFUs) are common and disabling, giving rise to significant morbidity and mortality as well as worldwide socioeconomic problems. Despite treatment, DFUs readily become chronic wounds and may lead to major lower limb amputations.
Ho, TK, Leigh, RD, Tsui, J
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Larval therapy for leg ulcers (VenUS II) : randomised controlled trial [PDF]
, 2009 Objective To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers. Design Pragmatic, three armed randomised controlled trial.
Bland, J. Martin +10 more
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Hydroxyurea ulcers of unusual location: a case report and review of literature
Forum of Clinical Oncology, 2023 Hydroxyurea is a cytotoxic drug that has been used for decades for the treatment of various entities, mostly hematologic, especially polycythemia vera.
Miguel Mansilla-Polo +2 more
doaj +1 more source
Congenital Inferior Vena Cava Agenesis with Ulceration and Deep Vein Thrombosis
European Journal of Case Reports in Internal Medicine, 2021 Objectives: This is one of the few case reports of congenital inferior vena cava atresia (IVCA) with extensive bilateral lower extremity ulcers. Background: IVCA is a congenital anomaly characterized by poor venous return in the lower extremities with ...
Melanie Menning, Mira Yousef
doaj +1 more source
Epidemiological Study of Ulcers of the Lower Limb in a Tertiary Care Teaching Institute [PDF]
Perspectives In Medical Research, 2020 Lower limb ulcers are common in old age group there are several causes which includes venous valve insufficiency, diabetes mellitus, skin malignancies.
Sudhir Adepu
doaj +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Postgraduate Medical Journal, 1995 Abstract This paper reports a rare form of ulceration of the lower leg and, as a result of subsequent investigations and literature review, readdresses a recent debate regarding the legitimate classification of these ulcers as a separate disease entity.
S D, Shutler +2 more
openaire +2 more sources
Inter-rater reliability of the EPUAP pressure ulcer classification system using photographs [PDF]
, 2004 Background. Many classification systems for grading pressure ulcers are discussed in the literature. Correct identification and classification of a pressure ulcer is important for accurate reporting of the magnitude of the problem, and for timely ...
AHCPR +31 more
core +1 more source