Results 51 to 60 of about 317,157 (293)

Immune-Related Adverse Events Mimicking Behcet's Disease in a Gastric Cancer Patient Following Camrelizumab Treatment [PDF]

Iranian Journal of Immunology, 2020
Background: Anti-programmed cell death 1(anti-PD-1) antibodies are immune checkpoint inhibitors (ICIs) used as a treatment option for a number of cancers to expand lifespan.
Sha Zhang, Dong Wang, Ping Ding, Yu Zhao, Xiao Zhang, Qun Zhao   +5 more
doaj   +1 more source

Lipschütz ulcers: uncommon diagnosis of vulvar ulcerations [PDF]

BMJ Case Reports, 2016
Aetiological diagnosis of genital ulcers is still a challenge in clinical practice. The cause is mostly infectious, but it may otherwise be a presentation of a wide variety of pathologies, such as autoimmune (eg, Behcet’s disease), cancer or inflammatory processes. The Lipschutz ulcer is a non-sexually transmitted condition.
Mourinha, Vera, Costa, Sara, Urzal, Cecilia, Guerreiro, Fernando   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Supervised exercise training as an adjunctive therapy for venous leg ulcers: study protocol for a randomised controlled feasibility trial [PDF]

, 2015
Background Venous leg ulcers are common, chronic wounds that are painful and reduce quality of life. Compression therapy is known to assist in the healing of venous leg ulceration.
Gumber, Anil, Michaels, Jonathan, Tew, G.A., Middleton, Geoff, Anil Gumber (3400901), Jonathan Michaels (3400904), Geoff Middleton (3400895), Klonizakis, Markos, Tew, Garry, Garry Tew (3400907), Helen Crank (3400898), Gumber, A., Tew, Garry A., Michaels, J., Crank, H., Klonizakis, M., Crank, Helen, Middleton, G., Markos Klonizakis (3400910)   +18 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Differentiating Arteriolosclerotic Ulcers of Martorell from Other Types of Leg Ulcers Based on Vascular Histomorphology [PDF]

, 2021
Clinical differential diagnosis of arteriolosclerotic ulcers of Martorell is challenging due to the lack of clearly affirmative instrument-based diagnostic criteria.
Bossart, Simon, Anzengruber, F, Beltraminelli, H, Anzengruber, Florian, Tzaneva, Stanislava, Hafner, Jürg, Hafner, J, Böhler, K, Meier-Schiesser, Barbara, Meier-Schiesser, B, Tschandl, Philipp, Deinsberger, Julia, Petzelbauer, P, Brugger, Jonas, Deinsberger, J, Beltraminelli, Helmut, Weber, Benedikt, Weber, B, Bossart, S, Tzaneva, S, Petzelbauer, Peter, Böhler, Kornelia, Tschandl, P, Brugger, J, Simon Bossart, K Böhler, Jürg Hafner, Barbara Meier-Schiesser, Stanislava Tzaneva, F Anzengruber, H Beltraminelli, S Tzaneva, S Bossart, B Meier-Schiesser, J Brugger, Peter Petzelbauer, Florian Anzengruber, J Hafner, Jonas Brugger, P Petzelbauer, B Weber, P Tschandl, Helmut Beltraminelli, J Deinsberger, Julia Deinsberger, Kornelia Böhler, Philipp Tschandl, Benedikt Weber   +47 more
core   +2 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source