Results 211 to 220 of about 3,052,249 (309)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Alloy Selection and Manufacturing Technologies for Total Ankle Arthroplasty: A Narrative Review. [PDF]

Materials (Basel)
Mitra K, Movva AK, Sohn MO, Tennyson JM, Talaski GM, Adams SB, Anastasio AT.   +6 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Strengthening of corroded RC slab-column joints using thin-ply hybrid FRP under punching shear. [PDF]

Sci Rep
Gomaa AM, Ahmed MA, Khafaga SA, Lotfy EM, Hosny S.   +4 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Carcass Traits and Meat Quality of Surgically Castrated and Immunocastrated Pigs at Two Slaughter Weights. [PDF]

Animals (Basel)
Zhdanov DV, Mykhalko OH, Povod MH, Zamaratskaia G.   +3 more
europepmc   +1 more source

Optimum Carbon Fiber Reinforced Polymer (CFRP) Design for Flexural Strengthening of Cantilever Concrete Walls Using Artificial Neural Networks. [PDF]

Polymers (Basel)
Bekdaş G, Khalbous A, Nigdeli SM, Işıkdağ Ü.   +3 more
europepmc   +1 more source

Numerical investigation on performance of concrete-steel composite beams incorporating multi-transverse holes. [PDF]

Sci Rep
Fayed S, Ghalla M, Mlybari EA, Bazuhair RW, Alaskar A, Yehia SA.   +5 more
europepmc   +1 more source