Results 51 to 60 of about 1,100 (175)

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, Volume 292, Issue 21, Page 5802-5817, November 2025.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

A Heavy-metal Scenario of Ultra-high-energy Cosmic Rays

The Astrophysical Journal Letters
The mass composition of ultra-high-energy cosmic rays is an open problem in astroparticle physics. It is usually inferred from the depth of the shower maximum ( X _max ) of cosmic-ray showers, which is only ambiguously determined by modern hadronic ...
Jakub Vícha, Alena Bakalová, Ana L. Müller, Olena Tkachenko, Maximilian K. Stadelmaier   +4 more
doaj   +1 more source

Evolutionary and functional relationships between plant and microbial C1 metabolism in terrestrial ecosystems

New Phytologist, Volume 248, Issue 3, Page 1132-1153, November 2025.
Summary One‐carbon (C1) metabolism, centered on the universal methyl donor S‐adenosyl methionine (SAM), plays critical roles in biosynthesis, redox regulation, and stress responses across plants and microbes. A recently proposed photosynthetic C1 pathway links SAM methyl groups directly to RuBisCO‐mediated CO2 assimilation and integrates with nitrogen ...
Kolby J. Jardine, Linnea K. Honeker, Zhaoxin Zhang, Steve Kwatcho Kengdo, Yuguo Yang, Joseph Roscioli, William J. Riley   +6 more
wiley   +1 more source

Cosmic-Ray Constraints on the Flux of Ultrahigh-energy Neutrino Event KM3-230213A

The Astrophysical Journal
The detection of a ≃220 PeV muon neutrino event by the KM3NeT telescope offers an unprecedented opportunity to probe the Universe at extreme energies.
Saikat Das, Bing Zhang, Soebur Razzaque, Siyao Xu   +3 more
doaj   +1 more source

Atomic and Molecular Ions in Atmospheric Chemistry: Interfacial Reactivity, Emerging Mechanisms, and Future Perspectives

Journal of Geophysical Research: Atmospheres, Volume 130, Issue 20, 28 October 2025.
Abstract Atomic and molecular ions (AIs and MIs) play distinct yet complementary roles in atmospheric chemistry, influencing aerosol reactivity, cloud formation, and climate. AIs, with high charge density and structural simplicity, generate intense interfacial fields that accelerate reactions such as halogen activation and sulfate formation.
Xiangrui Kong, Markus Ammann, Christian George, Daniel Knopf   +3 more
wiley   +1 more source

UHECRs Propagation and Their Multimessengers: Upper Limits and the Impact of the Extragalactic Magnetic Field

The Astrophysical Journal
The detection of high-energy astrophysical multimessengers establishes a connection between ultra-high-energy cosmic rays (UHECRs) and powerful cosmic accelerators.
Rodrigo Sasse, Rubens Costa Jr., Adriel G.B. Mocellin, Carlos H. Coimbra-Araujo, R. C. Dos Anjos   +4 more
doaj   +1 more source

The Air Microwave Yield (AMY) experiment to measure the GHz emission from air shower plasmas

EPJ Web of Conferences, 2013
The AMY experiment aims to measure the Microwave Bremsstrahlung Radiation (MBR) emitted by air-showers secondary electrons accelerating in collisions with neutral molecules of the atmosphere. The measurements are performed at the Beam Test Facility (BTF)
Smida R., Salina G., Settimo M., Salamida F., Fernandez G. Rodriguez, Rizi V., Riegel M., Petrera S., Privitera P., Perrone L., Monasor M., Martello D., Iarlori M., Luis P. Facal San, Engel R., Creti P., De Mitri I., Di Giulio C., Verzi V., Coluccia M.R., Cataldi G., Bohacova M., Alvarez-Muñiz J., Werner F., Williams C.   +24 more
doaj   +1 more source

Ultra-high energy cosmic rays: 40 years retrospective of continuous observations at the Yakutsk array: Part 1. Cosmic ray spectrum in the energy range 1015–1018 eV and its interpretation

EPJ Web of Conferences, 2015
The experimental data on the cosmic ray energy spectrum obtained from the Small Cherenkov Array in Yakutsk on the measurement of Cherenkov radiation in showers with energy 1015–1018 eV are discussed.
Knurenko Stanislav, Petrov Igor, Petrov Zim, Sleptsov Ivan   +3 more
doaj   +1 more source

Precise Measurement of the Cosmic-Ray Spectrum and 〈ln A〉 by LHAASO: Connecting the Galactic to the Extragalactic Components

The Astrophysical Journal
Recently, the LHAASO Collaboration has provided precise measurements of the cosmic rays (CRs) all-particle energy spectrum and mean logarithmic mass $\left\langle \mathrm{ln}A\right\rangle $ from 0.3 to 30 PeV. Combining the CR measurements by AMS-02 and
Xing-Jian Lv, Xiao-Jun Bi, Kun Fang, Yi-Qing Guo, Hui-Hai He, Ling-Ling Ma, Peng-Fei Yin, Qiang Yuan, Meng-Jie Zhao   +8 more
doaj   +1 more source

Observation of the Galactic Center PeVatron beyond 100 TeV with HAWC

The Astrophysical Journal Letters
We report an observation of ultrahigh-energy (UHE) gamma rays from the Galactic center (GC) region, using 7 yr of data collected by the High-Altitude Water Cherenkov (HAWC) Observatory.
A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, C. de León, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. DuVernois, J. C. Díaz-Vélez, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, H. Goksu, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, T. B. Humensky, P. Hüntemeyer, A. Iriarte, S. Kaufmann, D. Kieda, A. Lara, W. H. Lee, J. Lee, H. León Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, J. A. Morales-Soto, E. Moreno, M. Mostafá, M. Najafi, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, X. Wang, Z. Wang, I. J. Watson, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou   +101 more
doaj   +1 more source