Results 151 to 160 of about 20,472,467 (275)

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

NDFIP2 Suppresses Colorectal Cancer Metastasis Through DDX3X‐Dependent R‐Loop Remodeling and GNG13 Transcriptional Activation

Advanced Science, EarlyView.
NDFIP2 recruits NEDD4 to promote K48‐linked ubiquitination and proteasomal degradation of DDX3X, leading to R‐loop accumulation and CTCF‐dependent suppression of GNG13 transcription. Consequently, PI3K/AKT signaling, EMT, stemness, and colorectal cancer metastasis are inhibited.
Enjian Zhang, Yanfang Li, Jiaxin Shu, Shang Xu, Heng Lv, Chong Zhang, Pengbo Zhang, Nai Wu, Shuai Gong, Xiuzhong Zhang, Zeqiang Ren, Xin Liu, Yi Zhang   +12 more
wiley   +1 more source

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

Advanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni, Xinyi Shi, Tong Zhu, Guanrong Li, Lei Chang, Shengtao Li, Jingyi Chi, Chen Shi, Zeming Hu, Rong Xu, Yingchun Zhu, Yang Luo, Yichen Chen, Fan Yang, Yabin Zhu   +14 more
wiley   +1 more source

Correction: Evaluation of ß-lactamase-induced inactivation of penicillin G and cefoperazone in spiked ultra-high temperature and raw unpasteurized milk. [PDF]

Front Vet Sci
Frontiers Production Office.
europepmc   +1 more source

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

Advanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu, Wencai Liu, Xinyue Yang, Hanzhe Zhang, Hui Xu, Xin Wang, Weimin Lin, Xiping Jiang, Chenrui Yuan, Yifei Wang, Weilin Yu, Yamin Li, Wei Song, Yaohua He   +13 more
wiley   +1 more source

Comparative Stability of Carotenoids in Grass-Fed and Grain-Fed Milk: Impact of Thermal Processing and the Protective Role of the Milk Matrix. [PDF]

J Food Sci
Xu X, Chen X, Song X, Xiong Z, Zhang H, Yang Y, Yang Y, Ai L, Wang G.   +8 more
europepmc   +1 more source

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

Pharmacokinetic Tuning Redirects β‐Lapachone From NQO1 Bioactivation to Vimentin‐Targeted Oxidation in Cancer

Advanced Science, EarlyView.
Pharmacokinetic tuning acts as a programmable mechanistic switch for β‐lap. Sustained low‐concentration exposure redirects β‐lap from NQO1 bioactivation to direct oxidation of vimentin, driving disulfide crosslinking, proteasomal overload and ferroptosis.
Lei Dou, Huiqin Liu, Kaixin Wang, Yi Xia, Zhidong Chen, Feng Qian   +5 more
wiley   +1 more source

A Sensitive LC-MS/MS Method for Quantifying Beta-Casomorphin 5 in Pasteurized Milk. [PDF]

Food Sci Nutr
Nguyen DD, Solah V, Daubney S, Kowalczyk M, Hunt W.   +4 more
europepmc   +1 more source

Targeting a Calcium‐Associated Mitochondrial Vulnerability in TET2‐Deficient Myeloid Cells

Advanced Science, EarlyView.
Reduced TET2 function creates a calcium‐associated mitochondrial vulnerability in macrophages that is preferentially exploited by Lanatoside C. The resulting stress promotes apoptosis of TET2‐deficient macrophages, reduces inflammatory and fibrotic injury in human cardiac organoids, and highlights a genotype‐associated myeloid liability that may be ...
Yue Wang, Minh Duc Pham, Despina Stefanoska, Ting Yuan, Arka Provo Das, Chaonan Zhu, Meiqian Wu, Thanh Thuy Duong, Jaskiran Kaur, Yu Hao, Johannes Krefting, Marius Schwab, Jonathan Ward, Maria Duda, Wesley Abplanalp, Moritz von Scheidt, Andreas M. Zeiher, Stefanie Dimmeler, Jaya Krishnan   +18 more
wiley   +1 more source