Results 201 to 210 of about 156,660 (284)

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials. [PDF]

Small
Alleva N, Zhang J, Ng DYW, Weil T, John T.   +4 more
europepmc   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Application of Membrane Materials in Bioseparation and Downstream Processing. [PDF]

Membranes (Basel)
Zhang W, Kong L.
europepmc   +1 more source

Ultrasound–triggered tumor‐selective nitric oxide release enhances tumor penetration of antibody–conjugated nanomedicine

Interdisciplinary Medicine, EarlyView.
Ultrasound‐triggered nitric oxide release from S‐nitrosated hyaluronic acid (HA‐SNO) induces tumor vasodilation and disrupts the vascular barrier, potently enhancing the intratumoral penetration of antibody‐conjugated nanomedicines. Abstract The tumor vascular barrier restricts the penetration of antibody‐conjugated nanomedicine, severely limiting its ...
Xiaodong Wang, Ruifeng Duan, Xin Chen, Tongjun Liu, Zhilin Liu   +4 more
wiley   +1 more source

Global profiling of α-glucosidase inhibitors from Citri Reticulatae Pericarpium based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method. [PDF]

PLoS One
Wang H, Yin Q, Lin Z, Ma Q, Zhang Z, Jia J.   +5 more
europepmc   +1 more source

Determination of digestible indispensable amino acid score for salmon hydrolysate proteins

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Salmon products are excellent foods that contain indispensable nutrients including fatty acids and amino acids (AA), but during processing, salmon co‐products that cannot be used for the primary purpose are also generated. Examples of such co‐products include salmon protein hydrolysate concentrate (SPHC) and salmon protein ...
Natalia S Fanelli, Juliana CFR Martins, Hans H Stein   +2 more
wiley   +1 more source

Cardiopulmonary Bypass Circuit Modification Proposal for Modified Ultrafiltration in Children. [PDF]

Braz J Cardiovasc Surg
Scaranaro AV, Policarpo RDS, Croti UA, Finoti RG.   +3 more
europepmc   +1 more source

Impact of spring rape varieties on protein extraction from press cake, emulsifying properties and antinutrient content

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Rapeseed is the second most cultivated oilseed globally after soybean and a protein‐rich press cake is generated after liberation of the oil. However, its use in food applications is limited by high levels of anti‐nutrients such as glucosinolates and phytic acid. Although differences between botanical varieties are known, controlled
Cecilia Ahlström, Evangelia Papagianni, Eu Sheng Wang, Inger‐Cecilia Mayer Labba, Ann‐Sofie Sanberg, Emil Andersson, Johan Thuvander, Karolina Östbring   +7 more
wiley   +1 more source

Fluid removal improves muscle performance and weakness in critically ill patients: a pilot study. [PDF]

Intensive Care Med Exp
Arancibia N, López R.
europepmc   +1 more source