Results 231 to 240 of about 103,585 (306)
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.ABSTRACT Malignant and non‐malignant cells within the tumor microenvironment (TME) actively secrete extracellular vesicles (EVs) that may mediate intercellular communication or enter the blood stream. Circulating EVs in Diffuse Large B‐Cell Lymphoma (DLBCL) patients are a promising source of liquid biopsy biomarkers; however, whether different cellular
Filippo Maltoni +17 more
wiley +1 more source
Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression
MedComm, Volume 7, Issue 4, April 2026.A cell‐permeable nanobody strategy was developed to target the intrinsically disordered oncoprotein c‐MYC. A synthetic nanobody, M4, binds the central PEST region of c‐MYC (241–263) and promotes c‐MYC degradation by enhancing Thr58 phosphorylation. Conjugation of M4 to a cell‐penetrating peptide (CPP) generates CPM4, which efficiently accumulates in ...
Yuanyuan Xue +7 more
wiley +1 more source
Molecular Ecology Resources, Volume 26, Issue 3, April 2026.ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Sangil Kim, Brian D. Farrell
wiley +1 more source
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley +1 more source
Viscoelastic Behaviors of Hyaluronic Derivatives as a Function of pH, Salt, and Temperature
Journal of Polymer Science, Volume 64, Issue 6, Page 1505-1517, 15 March 2026.Viscoelastic properties of hyaluronic acid grafted with polyether side‐chains (HA‐PEPO) can be controlled in aqueous media over more than three decades of amplitude with the possibility to get liquid or gel states, regardless of temperature, as well as sol/gel transitions induced by cooling or heating by the interplay between hydrogen bonds ...
Yogesh Kadam +6 more
wiley +1 more source
Advanced Functional Materials, Volume 36, Issue 25, 26 March 2026.Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi +7 more
wiley +1 more source
Multiphysics‐Driven Assembly of Biomimetic Vesicles
Advanced Materials, Volume 38, Issue 13, 3 March 2026.Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko +16 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 14, 6 March 2026.A recombinant spider silk protein was functionalized by incorporating genetically encoded bio‐orthogonal reactive azido‐groups. The azido‐functionalized proteins were produced in a scalable biotechnological process, and particles, films, as well as nanofibers were established as anchorage for fully functional antibodies via site‐specific bio‐orthogonal
Claudia Lacombe +4 more
wiley +1 more source
Advanced Materials Interfaces, Volume 13, Issue 5, 4 March 2026.Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source